Anthropometric Measurements as Predictors of Low Birth Weight Among Tanzanian Neonates: A Hospital-Based Study
November 7, 2025
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Brand Name :
Advil PM
(United States) [Available] ,FT Ibuprofen PM
(United States) [Available] ,Motrin PM
(United States) [Available]Synonyms :
diphenhydramine/ ibuprofen
Class :
Sedative/Hypnotics; NSAIDs
Brand Name :
Advil PM
(United States) [Available] ,FT Ibuprofen PM
(United States) [Available] ,Motrin PM
(United States) [Available]Synonyms :
diphenhydramine/ ibuprofen
Class :
Sedative/Hypnotics; NSAIDs
Dosage Forms & Strengths  Â
CapletÂ
25 mg/200 mgÂ
38 mg/200 mgÂ
Dosage Forms & Strengths  Â
CapletÂ
25 mg/200 mgÂ
38 mg/200 mgÂ
Refer to adult dosingÂ
choline magnesium trisalicylate
NSAIDs may enhance the adverse/toxic effect of Salicylates
may enhance the anticoagulant effect of Vitamin K Antagonists
may enhance the anticoagulant effect of Vitamin K Antagonists
may enhance the anticoagulant effect of Vitamin K Antagonists
may enhance the anticoagulant effect of Vitamin K Antagonists
may enhance the anticoagulant effect of Vitamin K Antagonists
it may enhance the adverse/toxic effect of apixaban
NSAIDs may enhance the anticoagulant effect of Heparin
NSAIDs may enhance the anticoagulant effect of Heparin
NSAIDs may increase the serum concentration of Lithium
NSAIDs may diminish the diuretic effect of loop diuretics
NSAIDs may diminish the diuretic effect of loop diuretics
NSAIDs may diminish the diuretic effect of loop diuretics
it may enhance the antiplatelet effect of Nonsteroidal Anti-Inflammatory Agents
it may enhance the antiplatelet effect of Nonsteroidal Anti-Inflammatory Agents
it may enhance the antiplatelet effect of Nonsteroidal Anti-Inflammatory Agents
it may enhance the antiplatelet effect of Nonsteroidal Anti-Inflammatory Agents
it may enhance the antiplatelet effect of Nonsteroidal Anti-Inflammatory Agents
apixaban: it may enhance the toxic effect of Anti-Inflammatory Agents
enoxaparin: it may enhance the toxic effect of Anti-Inflammatory Agents
heparin: it may enhance the toxic effect of Anti-Inflammatory Agents
abrocitinib: it may enhance the toxic effect of Anti-Inflammatory Agents
acemetacin may enhance the adverse/toxic effect of Nonsteroidal Anti-Inflammatory Agents
Ketorolac may enhance the adverse/toxic effect of Nonsteroidal Anti-Inflammatory Agents
it May diminish the therapeutic effect of Loop Diuretics
it May diminish the therapeutic effect of Loop Diuretics
it May diminish the therapeutic effect of Loop Diuretics
NSAIDS may enhance the neuroexcitatory and/or seizure-potentiating effect of quinolones
NSAIDS may enhance the neuroexcitatory and/or seizure-potentiating effect of quinolones
NSAIDs may diminish the antihypertensive effect of Beta-Blockers
NSAIDs may diminish the antihypertensive effect of Beta-Blockers
NSAIDs may diminish the antihypertensive effect of Beta-Blockers
NSAIDs may diminish the antihypertensive effect of Beta-Blockers
NSAIDs may diminish the antihypertensive effect of Beta-Blockers
NSAIDs may enhance the adverse/toxic effect of Bisphosphonate Derivatives
NSAIDs may enhance the adverse/toxic effect of Bisphosphonate Derivatives
NSAIDs may enhance the adverse/toxic effect of Bisphosphonate Derivatives
NSAIDs may enhance the adverse/toxic effect of Bisphosphonate Derivatives
corticosteroids may enhance the adverse/toxic effect of NSAIDs
corticosteroids may enhance the adverse/toxic effect of NSAIDs
corticosteroids may enhance the adverse/toxic effect of NSAIDs
corticosteroids may enhance the adverse/toxic effect of NSAIDs
corticosteroids may enhance the adverse/toxic effect of NSAIDs
NSAIDsmay diminish the antihypertensive effect of Potassium-Sparing Diuretics
NSAIDsmay diminish the antihypertensive effect of Potassium-Sparing Diuretics
NSAIDs May diminish the anti-hypertensive effect of Beta-Blockers
NSAIDs May diminish the anti-hypertensive effect of Beta-Blockers
NSAIDs May diminish the anti-hypertensive effect of Beta-Blockers
NSAIDs May diminish the anti-hypertensive effect of Beta-Blockers
NSAIDs May diminish the anti-hypertensive effect of Beta-Blockers
ACE Inhibitors may enhance the adverse/toxic effect of NSAIDs
ACE Inhibitors may enhance the adverse/toxic effect of NSAIDs
ACE Inhibitors may enhance the adverse/toxic effect of NSAIDs
ACE Inhibitors may enhance the adverse/toxic effect of NSAIDs
ACE Inhibitors may enhance the adverse/toxic effect of NSAIDs
may increase the risk of adverse effects
may increase the risk of adverse effects
may increase the risk of adverse effects
may increase the risk of adverse effects
may increase the risk of adverse effects
may increase the risk of adverse effects
may increase the risk of adverse effects
may increase the risk of adverse effects
may increase the risk of adverse effects
may increase the risk of adverse effects
it may increase the effect of serotonergic agents
Nonsteroidal Anti-Inflammatory Agents may diminish the antihypertensive effect of aliskiren
angiotensin II Receptor Blockers may enhance the adverse/toxic effect of Nonsteroidal Anti-Inflammatory Agents
angiotensin II Receptor Blockers may enhance the adverse/toxic effect of Nonsteroidal Anti-Inflammatory Agents
angiotensin II Receptor Blockers may enhance the adverse/toxic effect of Nonsteroidal Anti-Inflammatory Agents
angiotensin II Receptor Blockers may enhance the adverse/toxic effect of Nonsteroidal Anti-Inflammatory Agents
angiotensin II Receptor Blockers may enhance the adverse/toxic effect of Nonsteroidal Anti-Inflammatory Agents
angiotensin-Converting Enzyme Inhibitors may enhance the adverse/toxic effect of Nonsteroidal Anti-Inflammatory Agents
angiotensin-Converting Enzyme Inhibitors may enhance the adverse/toxic effect of Nonsteroidal Anti-Inflammatory Agents
angiotensin-Converting Enzyme Inhibitors may enhance the adverse/toxic effect of Nonsteroidal Anti-Inflammatory Agents
angiotensin-Converting Enzyme Inhibitors may enhance the adverse/toxic effect of Nonsteroidal Anti-Inflammatory Agents
angiotensin-Converting Enzyme Inhibitors may enhance the adverse/toxic effect of Nonsteroidal Anti-Inflammatory Agents
bile Acid Sequestrants may decrease the absorption of Nonsteroidal Anti-Inflammatory Agents
may diminish the therapeutic effect of angiotensin II Receptor Blockers
choline magnesium trisalicylate
may enhance the adverse/toxic effect of salicylates
NSAIDs may enhance the adverse/toxic effect of metformin
methotrexate: it may enhance the toxic effect of Anti-Inflammatory Agents
pralatrexate: it may enhance the toxic effect of Anti-Inflammatory Agents
rivaroxaban: it may enhance the toxic effect of Anti-Inflammatory Agents
sincalide: it may enhance the toxic effect of Anti-Inflammatory Agents
acemetacin: it may enhance the toxic effect of Anti-Inflammatory Agents
ketorolac: it may enhance the toxic effect of Anti-Inflammatory Agents
macimorelin: it may enhance the toxic effect of Anti-Inflammatory Agents
phenylbutazone: it may enhance the toxic effect of Anti-Inflammatory Agents
urokinase: it may enhance the toxic effect of Anti-Inflammatory Agents
vancomycin: it may enhance the toxic effect of Anti-Inflammatory Agents
acalabrutinib: it may enhance the toxic effect of Anti-Inflammatory Agents
cephalothin: it may enhance the toxic effect of Anti-Inflammatory Agents
dasatinib: it may enhance the toxic effect of Anti-Inflammatory Agents
deferasirox: it may enhance the toxic effect of Anti-Inflammatory Agents
Actions and Spectrum:Â
diphenhydramine, an antihistamine, is used to treat allergy symptoms like scratchy throat, runny nose, and watery eyes. It functions by inhibiting the effects of histamine, a chemical the body releases in reaction to allergens. In addition to its ability to cure insomnia. diphenhydramine also possesses calming qualities that make it a moderate tranquillizer.Â
The nonsteroidal anti-inflammatory medicine (NSAID) ibuprofen, on the other hand, is used to treat inflammation, fever, and discomfort. It functions by preventing the body from producing prostaglandins, which are chemicals released in reaction to damage or inflammation. ibuprofen is frequently used to treat ailments including arthritis, menstrual cramps, headaches, and toothaches.Â
Frequency not defined Â
For ibuprofenÂ
RashÂ
VomitingÂ
EdemaÂ
TinnitusÂ
NauseaÂ
Epigastric painÂ
For diphenhydramineÂ
ConfusionÂ
XerostomiaÂ
Pharyngeal and nasal mucosa drynessÂ
SedationÂ
May decrease cognitive function in geriatric patientsÂ
Thick sputumÂ
Anticholinergic effectsÂ
Black Box WarningÂ
For its sedative effects, diphenhydramine may include a black box warning, especially in older persons. It may make you feel confused or lightheaded and raise your chance of falling. Also, people with asthma or other respiratory disorders should take caution when using diphenhydramine since it has the potential to cause respiratory depression.Â
For its elevated risk of cardiovascular events including heart attack and stroke, ibuprofen may have a black box warning. Those who already have cardiovascular disease are more at risk for this, and long-term ibuprofen usage may make the risk worse.Â
Contraindication/Caution:Â
Contraindication:Â
Caution:Â
Pregnancy warnings:    Â
Pregnancy category: NAÂ
Lactation: Excretion into human milk is knownÂ
Pregnancy Categories:        Â
Category A: Studies that were well-controlled and met expectations revealed no risk to the fetus in either the first or second trimester.Â
Category B: There were lack of studies on pregnant women and no evidence of risk to the foetus in animal experiments.  Â
Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.   Â
Category D: adequate data available with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.  Â
Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women.   Â
Category N: There is no data available for the drug under this category
PharmacologyÂ
diphenhydramine is an antihistamine that works by inhibiting the effects of histamine, a chemical that the body releases in reaction to allergens. diphenhydramine helps to reduce allergy symptoms such itchiness, sneezing, runny nose, and watery eyes by inhibiting the activity of histamine.Â
ibuprofen is a nonsteroidal anti-inflammatory medicine (NSAID) that reduces pain and inflammation by inhibiting the body’s ability to make prostaglandins, which are chemicals that are created in reaction to injury or inflammation. ibuprofen aids in reducing inflammation, fever, and discomfort by preventing the formation of prostaglandins.Â
PharmacodynamicsÂ
As a competitive antagonist of histamine H1 receptors, diphenhydramine prevents histamine from binding to these receptors. diphenhydramine may pass the blood-brain barrier and bind to histamine H1 receptors in the brain, which may explain its sedative effects.Â
The prostaglandin-producing enzyme cyclooxygenase (COX) is non-selectively inhibited by the anti-inflammatory drug ibuprofen. It decreases the formation of prostaglandins, which cause pain, fever, and inflammation, by inhibiting COX. Inhibiting platelet aggregation, which raises the risk of bleeding, is another way that ibuprofen is known to act.Â
PharmacokineticsÂ
Absorption  Â
After oral treatment, diphenhydramine is quickly absorbed, reaching peak plasma concentrations in within two hours. Taking it with meals might slow down the absorption. ibuprofen is similarly quickly absorbed when taken orally, reaching peak plasma concentrations in within one to two hours.Â
DistributionÂ
ibuprofen and diphenhydramine are both strongly protein-bound drugs (about 98%), which implies that they bind to blood proteins and are not readily absorbed by tissues. They both have a distribution volume of around 1 L/kg.Â
MetabolismÂ
The primary metabolite of diphenhydramine is N-demethylated diphenhydramine, which is produced by the liver’s cytochrome P450 (CYP) system. ibuprofen is metabolized by the liver via glucuronidation and oxidation, with ibuprofen glucuronide being the main byproduct.Â
Elimination and excretionÂ
Both diphenhydramine and ibuprofen are largely excreted through the kidneys, with diphenhydramine being eliminated in the urine as a drug and metabolites that have not been altered, and ibuprofen being eliminated in the urine as a drug and metabolites that have not been altered. diphenhydramine has an elimination half-life of around 4 hours, whereas ibuprofen has an elimination half-life of about 2-4 hours.Â
Administration: Â
Products containing both ibuprofen and diphenhydramine are often sold as oral tablets or capsules.Â
Depending on the drug and the disease being treated, the frequency and interval of dose might also change.Â
Patient information leafletÂ
Generic Name: diphenhydramine/ibuprofenÂ
Why do we use diphenhydramine/ibuprofen?Â
Products containing both diphenhydramine and ibuprofen are frequently used to treat pain as well as symptoms of colds, the flu, and allergies.Â
The medication’s diphenhydramine component is an antihistamine that can aid with cold and allergy-related symptoms like runny nose, sneezing, and itching. Moreover, it can aid in easing the effects of sleeplessness and motion sickness. Â
The medicine contains ibuprofen, a nonsteroidal anti-inflammatory drug (NSAID) that can be used to treat inflammation and mild to moderate discomfort. It is frequently used to treat toothaches, muscular pains, menstrual cramps, headaches, and menopausal symptoms.Â
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