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Brand Name :
Anzemet
Synonyms :
dolasetron
Class :
5HT3 receptor antagonists
Brand Name :
Anzemet
Synonyms :
dolasetron
Class :
5HT3 receptor antagonists
Dosage Forms & Strengths
Solution
20mg/mL
Tablet
50mg
100mg
Dosage Forms & Strengths
Solution
20mg/mL
Tablet
50mg
100mg
it may enhance the qtc interval when combined with lofexidine
when both drugs are combined, there may be an increased risk or severity of QTC prolongation
QTc interval is increased both by lenvatinib and dolasetron
dolasetron and loperamide are both known to elevate the QTc interval
The potential for CNS depression may enhanced when dolasetron is used together with fencamfamin
When dolasetron is used together with niaprazine, the risk or seriousness of CNS depression is enhanced
When dolasetron is used together with levosulpiride, the risk or seriousness of CNS depression is enhanced
When dolasetron is used together with melitracen, this leads to enhanced risk or seriousness of CNS depression
When dolasetron is used together with adenosine, this leads to enhanced risk or seriousness of QTc prolongation
When dolasetron is used together with givinostat, this leads to enhanced risk or seriousness of Qtc prolongation
When acepromazine is used together with dolasetron , this leads to enhanced risk or seriousness of CNS depression
When indisulam is used together with dolasetron, this leads to a reduction in dolasetron metabolism
dolasetron: it may increase the central nervous system depressant activities of tolperisone
Adverse drug reactions
Frequency Defined
>10%
Diarrhea
Headache
1-10%
Abdominal pain
Bradycardia
Dyspepsia
Dizziness
Drowsiness
Fatigue
HTN
Hypotension
Abnormal liver function
Pain
Oliguria
Urinary retention
Pruritus
Chills
Tachycardia
Fever
Pregnancy warnings:
AU TGA pregnancy category: B1
US FDA pregnancy category: B
Lactation:
Excreted into human milk is unknown
Pregnancy Categories:
Category A: Satisfactory and well-controlled studies show no risk to the fetus in the first or later trimester.
Category B: No evidence shown of risk to the fetus found in animal reproduction studies, and there are not enough studies on pregnant women
Category C: Adverse effects on the fetus found with evidence in animal reproduction studies and no adequate evidence for a result in humans must take care of potential risks in pregnant women
Category D: adequate data available with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.
Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women.
Category N: There is no data available for the drug under this category
Patient Information Leaflet
Generic Name: dolasetron
Why do we use dolasetron?
dolasetron is an 5HT3 receptor antagonists used to treat Postoperative Nausea & Vomiting and Cancer Chemotherapy Induced Nausea & Vomiting.
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