doravirine, lamivudine, and tenofovir disoproxil fumarate

Action and Spectrum

Drug Interaction

Adverse Reaction

>10%: 

Rash  

Headache 

Pain  

Diarrhea  

Depression  

1-10%: 

Fever  

Abdominal pain  

Asthenia  

Anxiety  

Arthralgia  

Insomnia 

Pneumonia  

Myalgia  

Dizziness  

Lipodystrophy  

Peripheral neuropathy 

Black Box Warning

Contraindication / Caution

Doravirine, lamivudine and tenofovir disoproxil fumarate is contraindicated in patients hypersensitive to the active ingredient. 

Pregnancy / Lactation

Pregnancy consideration:  

The drug is not indicated during pregnancy. 

Breastfeeding warnings:  

The benefits of breastfeeding and the effects of the drug should be considered if administering the drug. 

Pregnancy category: 

• Category A: well-controlled and Satisfactory studies show no risk to the fetus in the first or later trimester.        
• Category B: there was no evidence of risk to the fetus in animal studies, and there were no enough studies of pregnant women        
• Category C: there was evidence of risk of adverse effects in animal reproduction studies and no adequate evidence in human studies must take care of potential risks in pregnant women        
• Category D: adequate data available with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.        
• Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women.        
• Category N: There is no data available for the drug under this category

Pharmacology

Adminstartion

Patient Information Leaflet

Patient information leaflet 

Generic Name: doravirine, lamivudine, and tenofovir disoproxil fumarate seltamivir 

Pronounced: doraa-vireen lam-i-vud-een ten-o-fo-vir diso-prok-sil fyoo-mar-ate sel-tam-ivir 

Why do we use doravirine, lamivudine, and tenofovir disoproxil fumarate? 

Doravirine, lamivudine, and tenofovir disoproxil fumarate belong to antivirals category. It treats HIV-1 infection.