droxicam

Action and Spectrum

Actions and Spectrum: 

Action: 

Anti-Inflammatory: Droxicam reduces inflammation by inhibiting the enzyme cyclooxygenase (COX), that is involved in synthesizing prostaglandins. Prostaglandins are mediators of inflammation, and by reducing their production, droxicam helps alleviate inflammatory responses. 

Spectrum: 

Rheumatoid Arthritis: Droxicam is commonly prescribed for the treatment of rheumatoid arthritis, an autoimmune disorder characterized by joint inflammation. 

Drug Interaction

Adverse Reaction

Frequency not defined  

Cramps 

Nausea 

Gastrointestinal pain 

Black Box Warning

Black Box Warning:  

None

Contraindication / Caution

Contraindication/Caution:  

Hypersensitivity: Individuals who have demonstrated hypersensitivity (allergic reactions) to droxicam or any other NSAID should avoid its use. 

Severe Renal Impairment: Individuals with severe kidney disease may experience worsening of their condition with the use of droxicam. This medication should be used with caution, and the dosage may need to be adjusted based on renal function. 

Severe Heart Failure: NSAIDs, including droxicam, may cause fluid retention and edema. It should be used with caution in patients with severe heart failure. 

Pregnancy and Breastfeeding:
It is generally advised to avoid the use of droxicam during the third trimester of pregnancy because there is a risk of adverse effects on the fetal cardiovascular system. It is also not recommended during breastfeeding. 

Pregnancy / Lactation

Pregnancy warnings:     

Pregnancy category: N/A 

Lactation: Excreted into human milk is unknown 

Pregnancy Categories:         

Category A: Studies that were well-controlled and met expectations revealed no risk to the fetus in either the first or second trimester. 

<b>Category B: There were a lack of studies on pregnant women and no evidence of risk to the fetus in animal experiments.   

Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.    

Category D: adequate data with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.   

Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women.    

Category N: There is no data available for the drug under this category

Pharmacology

Pharmacology: Droxicam is a nonsteroidal anti-inflammatory drug. Its main function is to alleviate pain and reduce inflammation linked to a range of conditions, including osteoarthritis and rheumatoid arthritis. 

Pharmacodynamics:  

Droxicam exerts its therapeutic effects by inhibiting the activity of cyclooxygenase (COX) enzymes, specifically COX-1 and COX-2. The enzymes play a crucial role in converting arachidonic acid into prostaglandins, which play a crucial role in the inflammatory response. Inhibition of COX enzymes lead to a decrease in prostaglandin synthesis, resulting in reduced inflammation, pain, and fever.  

Pharmacokinetics: 

Absorption 

Droxicam is well absorbed after oral administration. 

Distribution 

Droxicam has a high protein-binding capacity and is distributed widely throughout the body. 

Metabolism 

Droxicam undergoes hepatic metabolism to form various metabolites. 

Excretion and Elimination 

Droxicam and its metabolites excretion mainly occurs through urinary system. 

Adminstartion

Administration:  

The dosage of droxicam can vary based on the condition being treated. It’s essential to follow the prescribed dosage provided by your healthcare provider. 

Patient Information Leaflet

Patient information leaflet 

Generic Name: droxicam 

Why do we use droxicam?  

Droxicam is often prescribed to alleviate pain caused by conditions including ankylosing spondylitis, rheumatoid arthritis, and osteoarthritis. 

As an NSAID, droxicam helps reduce inflammation by inhibiting the production of certain chemicals in the body that contribute to inflammation. This property makes it effective in managing inflammatory conditions like arthritis.