eberconazole/mometasone

Action and Spectrum

Actions and Spectrum: 

Action: 

eberconazole 

eberconazole is an antifungal medication that belongs to the imidazole class of antifungals. Its primary action is to inhibit the growth of fungi by disrupting their cell membranes and disrupting their ability to synthesize ergosterol, a crucial component of fungal cell walls. By doing so, eberconazole effectively treats fungal infections, particularly those caused by dermatophytes, yeasts, and molds. 

mometasone 

mometasone is a corticosteroid medication works by diminishing inflammation and inhibiting the body’s immune response. mometasone acts on various cells and chemicals involved in the inflammatory process, which helps alleviate symptoms like redness, swelling, itching, and discomfort.  

Spectrum:  

eberconazole primarily targets fungal skin infections and is ineffective against bacterial or viral infections. It is used topically and is designed for external use on the skin. 

mometasone is primarily used to treat inflammatory conditions, such as skin disorders (topical formulations), allergic rhinitis (nasal spray), and asthma (inhaler). It is not effective against infections caused by fungi, bacteria, or viruses. 

Drug Interaction

Adverse Reaction

Frequency not defined  

Skin atrophy 

Pruritus 

Burning 

Black Box Warning

Black Box Warning:  

None

Contraindication / Caution

Contraindication/Caution:  

Hypersensitivity: Do not use eberconazole/mometasone if you are known to be hypersensitive or allergic to either eberconazole, mometasone, or any other ingredients in the medication. Allergic reactions can be severe and should be avoided. 

Perioral Dermatitis: This medication is generally not recommended for the treatment of perioral dermatitis, a facial rash that typically affects the area around the mouth. The use of topical corticosteroids like mometasone can exacerbate this condition. 

Skin Infections Not Caused by Fungi: eberconazole/mometasone is primarily indicated for fungal skin infections. It should not be used to treat viral (e.g., herpes, chickenpox), bacterial (e.g., impetigo), or parasitic skin infections. In fact, using a corticosteroid like mometasone on bacterial or viral infections can make the condition worse. 

Pregnancy and Breastfeeding: Use caution during pregnancy and breastfeeding. Seek guidance from a medical professional to evaluate the possible advantages and disadvantages before considering the utilization of eberconazole/mometasone during these specific situations. 

Pregnancy / Lactation

Pregnancy warnings:     

Pregnancy category: N/A 

Lactation: Excreted into human milk is unknown 

Pregnancy Categories:         

Category A: Studies that were well-controlled and met expectations revealed no risk to the fetus in either the first or second trimester. 

<b>Category B: There were a lack of studies on pregnant women and no evidence of risk to the fetus in animal experiments.   

Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.    

Category D: adequate data with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.   

Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women.    

Category N: There is no data available for the drug under this category

Pharmacology

Pharmacology:  

eberconazole is an antifungal agent, specifically classified as an imidazole antifungal. mometasone belongs to the class of corticosteroids, specifically a medium-potency glucocorticoid. 

Pharmacodynamics:  

eberconazole 

eberconazole works by inhibiting the synthesis of ergosterol, a crucial component of fungal cell membranes. This disruption in fungal membrane structure leads to increased permeability and ultimately the death of the fungal cells. 

mometasone 

mometasone exerts its pharmacological effects by binding to glucocorticoid receptors, leading to the modulation of gene expression. This results in anti-inflammatory, immunosuppressive, and vasoconstrictive effects. mometasone reduces inflammation, itching, and redness associated with various skin conditions. 

Pharmacokinetics: 

Absorption 

eberconazole 

When applied topically to the skin, eberconazole is absorbed through the epidermis and dermis to reach the site of action, where it exerts its antifungal properties. mometasone is absorbed through the skin when applied topically and exerts its anti-inflammatory effects locally. 

Distribution 

After absorption, both eberconazole and mometasone may enter the systemic circulation, but their distribution is primarily localized to the skin and surrounding tissues. Systemic distribution is generally minimal with topical application. 

Metabolism 

eberconazole undergoes hepatic metabolism (metabolism in the liver) to form various metabolites, which are then excreted from the body. 

mometasone is metabolized primarily by the liver, which undergoes extensive first-pass metabolism. This metabolism helps reduce systemic exposure to the drug and minimize potential side effects. 

Excretion and Elimination 

The metabolites of eberconazole are eliminated from the body primarily through renal (kidney) excretion and, to a lesser extent, through feces. 

Metabolites of mometasone are also eliminated from the body mainly through urinary excretion. 

Adminstartion

Administration:  

Apply cream to the affected skin areas or as directed by your healthcare provider. 

Rub the cream or ointment gently into the skin until it is evenly distributed. 

Wash your hands after applying the cream. 

Patient Information Leaflet

Patient information leaflet 

Generic Name: eberconazole/mometasone 

Why do we use eberconazole/mometasone?  

The combination can provide relief from both the infection and its inflammatory symptoms. In some cases, fungal infections may be complicated by secondary bacterial or inflammatory reactions. The combination of eberconazole and mometasone can address both the fungal and inflammatory components, ensuring comprehensive treatment.  

Intertrigo is a condition where the skin folds rub against each other, leading to inflammation and sometimes fungal or bacterial infections. The combination of eberconazole and mometasone can address both the infection and the inflammation in these sensitive areas.