efavirenz

DRUG INTERACTION

Contraindicated  

Serious Use Alternative  

Monitor Closely  

Minor  

Frequency defined:   

>10% 

Skin rash 

Increased serum cholesterol  

1% to 10%: 

Angina pectoris 

Facial edema 

Atrial fibrillation 

Myocardial infarction 

Syncope 

Peripheral neuropathy 

Abnormal dreams 

Anxiety 

Confusion 

Drowsiness 

Disorientation 

Disturbance in attention 

Nervousness 

Hypoesthesia 

Prurigo 

Night sweats 

Xeroderma 

Diabetes  

lipohypertrophy 

pancreatitis 

stomatitis 

anorexia 

constipation  

flatulence  

gastritis  

Post-marketing: 

Angioedema 

Erythema multiforme 

Hemorrhagic stroke 

Rhabdomyolysis 

Stevens-Johnson syndrome 

Dress syndrome 

Pregnancy consideration: Efavirenz can moderately transfer across the human placenta. 

Lactation: efavirenz can be excreted in breast milk.  

Pregnancy category: 

• Category A: Satisfactory and well-controlled studies show no risk to the fetus in the first or later trimester. 
• Category B: There is no evidence of risk to the fetus found in animal reproduction studies, and there are not enough studies on pregnant women. 
• Category C: Adverse effects on the fetus found with evidence in animal reproduction studies and no adequate evidence for an effect in humans, care must be taken for potential risks in pregnant women 
• Category D: There is adequate data available with sufficient evidence of human fetal risk from various platforms, but despite potential risks may be used only in emergency cases for potential benefits. 
• Category X: Drugs listed in this category outweigh risks over benefits. These category drugs should be prohibited for pregnant women. 
• Category N: There is no data available for the drug under this category. 

Patient information leaflet 

Generic Name: Efavirenz  

Pronunciation: efavirenz  

Why do we use Efavirenz? 

It is used to treat viral infections such as HIV-1 infection.