enbucrilate

Action and Spectrum

Actions and spectrum: 

enbucrilate is a tissue adhesive commonly used in medical procedures. Its action involves the creation of a strong, flexible, and waterproof bond when applied to tissues. It is primarily used in surgical and medical applications for wound closure, wound dressings, and other tissue bonding needs.

enbucrilate provides an effective and efficient means of securing tissues together, making it valuable in various medical and surgical settings. Its spectrum of action primarily encompasses applications within the medical field, offering an alternative to traditional sutures or staples for certain wound closure and tissue sealing purposes. 

Drug Interaction

Adverse Reaction

Frequency not defined 

Skin irritation 

chronic pain 

inflammation 

Black Box Warning

Black Box Warning: 

There is no specific black box warning associated with enbucrilate. 

Contraindication / Caution

Contraindication/Caution: 

Contraindication: 

• Hypersensitivity: Individuals with a known hypersensitivity or allergy to enbucrilate or its components should not use the product. 
• Infected Wounds: enbucrilate is not typically used on wounds that are actively infected. In such cases, the infection needs to be treated and resolved before the product is applied. 
• Ocular Use: enbucrilate is not designed for use on the eyes. Eye-specific adhesives or medical products are used for ophthalmic procedures. 
• Allergic Reactions: While rare, some individuals may experience allergic reactions to enbucrilate. Any signs of an allergic response, such as rash, itching, or swelling, should be evaluated, and use should be discontinued if such reactions occur. 
• Tissue Suitability: The appropriateness of enbucrilate depends on the type and location of the tissue to be bonded. Not all tissues are suitable for adhesive closure, and the decision should be based on clinical judgment.

Caution: 

• Application Technique: enbucrilate should be applied following appropriate technique and manufacturer guidelines. Failure to do so may result in suboptimal bonding or complications. 
• Avoiding Contact with Eyes: enbucrilate should not come into contact with the eyes, as it is not designed for ophthalmic use. 
• Removal: In cases where the adhesive needs to be removed, the appropriate technique and solvents recommended by the manufacturer should be used to minimize damage to the underlying tissues. 
• Long-term Effects: The long-term effects of enbucrilate on tissues are not fully established, so careful monitoring of the bonded area is essential. 
• Wound Depth and Size: The choice to use enbucrilate may be influenced by the depth and size of the wound. Larger or deeper wounds may require other methods of closure, in addition to enbucrilate. 

Comorbidities: 

• Chronic Wounds: enbucrilate may be used in patients with chronic wounds, such as diabetic ulcers or pressure sores, where traditional wound closure methods may not be suitable. 
• Vascular Conditions: In patients with vascular conditions, such as peripheral artery disease, impaired blood flow can affect wound healing. enbucrilate may be used with caution in such cases, as adequate blood supply is important for tissue healing. 
• Immunocompromised Patients: Patients with compromised immune systems, such as those with HIV/AIDS or undergoing immunosuppressive therapy, may be at higher risk for infection. Careful wound care and infection prevention are essential when using enbucrilate in such individuals. 
• Skin Conditions: Patients with underlying skin conditions, such as psoriasis or eczema, may require additional consideration when using enbucrilate to ensure that the adhesive does not exacerbate skin problems. 

Pregnancy / Lactation

Pregnancy consideration: pregnancy category: not assigned 

Lactation: excreted into human milk: unknown  

Pregnancy category: 

• Category A: well-controlled and Satisfactory studies show no risk to the fetus in the first or later trimester. 
• Category B: there was no evidence of risk to the fetus in animal studies, and there were not enough studies on pregnant women. 
• Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.   
• Category D: adequate data with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits. 
• Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women. 
• Category N: There is no data available for the drug under this category. 

Pharmacology

Pharmacology: 

enbucrilate is a tissue adhesive with a pharmacological profile that involves its application as a topical adhesive for wound closure and tissue bonding. It functions by creating a strong and flexible bond when applied to tissues, helping to seal wounds and incisions. enbucrilate is often used as an alternative to traditional sutures or staples and provides an effective means of closing wounds in various medical and surgical procedures. Its action is primarily localized to the site of application, promoting tissue healing and minimizing the risk of infection.  

Pharmacodynamics: 

• Tissue Adhesion: enbucrilate is a cyanoacrylate-based tissue adhesive that polymerizes rapidly upon contact with tissues. It forms a strong and flexible bond that helps seal wounds, incisions, or tissue lacerations. This adhesive property allows for wound closure without the need for traditional sutures or staples. 
• Hemostasis: enbucrilate can contribute to hemostasis by sealing small blood vessels and capillaries, reducing the risk of bleeding in the bonded area. 
• Sealing and Closure: enbucrilate helps create a barrier that minimizes the risk of contamination & infection at the wound site. This can be particularly valuable in surgical and medical procedures where maintaining a sterile environment is essential. 
• Wound Healing: By providing a means for immediate wound closure, enbucrilate supports the early stages of wound healing and tissue repair. It can contribute to better cosmetic outcomes and reduced scarring. 

Pharmacokinetics: 

Absorption 

enbucrilate is applied topically to tissues during medical and surgical procedures. It does not undergo systemic absorption in the same way that pharmaceutical drugs do when taken orally or via injection. Instead, it rapidly polymerizes upon contact with tissues at the application site. 

Distribution 

enbucrilate’s distribution is localized to the area where it is applied. It forms a strong adhesive bond with the tissues at the application site, contributing to wound closure and tissue sealing. 

Metabolism 

enbucrilate does not undergo metabolic processes in the body, as it is not absorbed into the bloodstream to reach metabolic organs such as the liver. Its polymerization reaction is a chemical process that occurs at the tissue level. 

Elimination and excretion 

enbucrilate is not excreted from the body in the way that traditional drugs are eliminated. Once applied, it remains at the application site until the tissue adhesive degrades or is removed during medical follow-up procedures or tissue healing. 

Adminstartion

Administration: 

• Preparation: Before administering enbucrilate, the healthcare provider must ensure that the wound or incision is clean, dry, and properly prepared. Any foreign material, debris, or excess moisture should be removed from the area. 
• Application: enbucrilate is applied directly to the tissue that requires closure or bonding. It is typically supplied in a specialized applicator or container designed for controlled and precise application. The adhesive should be evenly applied to ensure a strong and secure bond. 
• Bond Formation: enbucrilate polymerizes rapidly upon contact with the tissue. The healthcare provider must hold the tissue in the desired position until the adhesive sets and a strong bond is formed. The time required for polymerization can vary depending on the specific product and application. 
• Assessment: Once the adhesive has fully set and the tissue is securely bonded, the healthcare provider will assess the quality of the closure. The site is inspected to ensure that the wound is appropriately sealed and that there is no tissue damage or excessive adhesive. 

Patient Information Leaflet

Patient information leaflet 

Generic Name: enbucrilate 

Pronounced: (En- Bu-cri-late)  

Why do we use enbucrilate? 

enbucrilate is used to close a variety of wounds, such as lacerations, incisions, and surgical wounds. It is particularly valuable for wounds in areas where sutures or staples may be challenging to use effectively. In dermatological procedures or cosmetic surgeries, enbucrilate can be employed to close and secure skin incisions or excisions.

enbucrilate is used to bond and stabilize fractured bones, primarily in small bone fractures. enbucrilate is used for tissue bonding in plastic and reconstructive surgeries where achieving precise and cosmetically appealing wound closure is essential.