enclomiphene

Action and Spectrum

Actions and Spectrum 

enclomiphene is used to induce ovulation in women who have ovulatory disorders or irregular menstrual cycles.  

By promoting the release of LH and FSH, it helps trigger the maturation and release of eggs from the ovaries, which can enhance fertility.

Drug Interaction

Adverse Reaction

Frequency not defined  

Hot flashes 

Metrorrhagia  

Breast discomfort 

Vomiting  

Bloating 

Enlarged ovary

Black Box Warning

Black Box Warning 

None 

Contraindication / Caution

Contraindication/Caution: 

Contraindication: 

• enclomiphene should not be used by individuals who have a known hypersensitivity or allergy to the drug or its components. 
• enclomiphene should not be used in the presence of ovarian cysts, as it can exacerbate the condition. 

Caution: 

• Patients with significant liver disease should use enclomiphene with caution. 
• In abnormal uterine bleeding cases avoid using this drug. 

Pregnancy / Lactation

Pregnancy consideration: 

Pregnancy category: N/A 

Lactation: Excretion into human milk is unknown  

Pregnancy Categories:         

Category A: well-controlled and Satisfactory studies show no risk to the fetus in the first or later trimester. 

Category B: there was no evidence of risk to the fetus in animal studies, and there were not enough studies on pregnant women.  

Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women. 

Category D: adequate data with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits. 

Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women. 

Category N: There is no data available for the drug under this category. 

Pharmacology

Pharmacology  

enclomiphene is classified as a selective estrogen receptor modulator (SERM). It acts as an antagonist at estrogen receptors in certain tissues, including the hypothalamus and pituitary gland, leading to reduced negative feedback of estrogen on these tissues. 

enclomiphene inhibits the negative feedback of estrogen on the hypothalamus and pituitary gland.  

Pharmacodynamics 

enclomiphene reduces the negative feedback of estrogen on the hypothalamus and pituitary gland. This effect leads to an increase in gonadotropin-releasing hormone (GnRH) production and secretion from the hypothalamus. 

Pharmacokinetics 

Absorption   

enclomiphene is readily absorbed from the gastrointestinal tract after oral intake.  

Distribution 

enclomiphene is distributed throughout the body. 

Metabolism 

enclomiphene undergoes hepatic metabolism in the liver. 

Elimination and excretion 

enclomiphene are excreted through the feces. 

Adminstartion

Administration 

enclomiphene is taken orally in the form of tablets.

Patient Information Leaflet

Patient information leaflet 

Generic Name: enclomiphene 

Why do we use enclomiphene? 

enclomiphene is used in women with anovulatory infertility, which means they have irregular or absent ovulation.   

It may also use as the first-line treatment for women with conditions like polycystic ovary syndrome (PCOS) or unexplained infertility who do not ovulate regularly.