- August 2, 2022
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Brand Name :
Comtan, SANDOZ Entacapone; TEVA-Entacapone
Synonyms :
Class :
Antiparkinson Agents, COMT Inhibitors
Dosage Forms & Strengths:
Tablet
200mg
Parkinson Disease
200 mg orally with each dose of levodopa/carbidopa maximum up to 8 times per day
Do not exceed the dose up to 1600 mg per day
Renal Impairment
Dose adjustment is not required
Hepatic Impairment
Dose adjustment is not required
200
mg
Orally
with each dose of levodopa/carbidopa maximum up to 8 times per day
Do not exceed the dose up to 1600 mg per day
Dose Adjustments
Renal Impairment
Dose adjustment is not required
Hepatic Impairment
Dose adjustment is not required
may diminish concentration of serum when combined with entacapone
may diminish concentration of serum when combined with entacapone
may diminish concentration of serum when combined with entacapone
may diminish concentration of serum when combined with entacapone
may have an increasingly adverse effect when combined with MAO inhibitors
may have an increasingly adverse effect when combined with MAO inhibitors
may have an increasingly adverse effect when combined with MAO inhibitors
may have an increasingly adverse effect when combined with MAO inhibitors
may have an increasingly adverse effect when combined with MAO inhibitors
may diminish the serum concentration of iron preparations
may enhance the adverse/toxic effect of MOA inhibitors
may enhance the adverse/toxic effect of MOA inhibitors
may enhance the adverse/toxic effect of MOA inhibitors
may enhance the adverse/toxic effect of MOA inhibitors
may enhance the adverse/toxic effect of MOA inhibitors
It may enhance the serum concentration when combined with COMT Substrates
It may enhance the serum concentration when combined with COMT Substrates
It may enhance the serum concentration when combined with COMT Substrates
It may enhance the serum concentration when combined with COMT Substrates
sapropterin may increase the risk of adverse/toxic effect of levodopa-containing products
may increase the risk of adverse effect
may increase the risk of adverse effect
may increase the risk of adverse effect
may increase the risk of adverse effect
may increase the risk of adverse effect
may increase the risk of adverse effect
may increase the risk of adverse effect
may increase the risk of adverse effect
may increase the risk of adverse effect
may increase the risk of adverse effect
may enhance the serum concentration of COMT Substrates
It may enhance the serum concentration when combined with COMT Substrates
It may enhance the serum concentration when combined with COMT Substrates
It may enhance the serum concentration when combined with COMT Substrates
It may enhance the serum concentration when combined with COMT Substrates
Adverse drug reactions:
Frequency defined:
>10%
Hyperkinesia
Dyskinesia
Nausea
Diarrhea
Urine discoloration
1-10%
Constipation
Back pain
Vomiting
Dry mouth
Hypokinesia
Dizziness
Abdominal pain
Fatigue
Dyspnea
Increased sweating
Agitation
Gastritis
Bacterial infection
Flatulence
Purpura
Asthenia
Hallucinations
Taste perversion
Frequency Not Defined
Postural hypotension
Confusion
Insomnia
Pregnancy warnings:
US FDA pregnancy category: C
Breastfeeding warnings:
The release of the drug into the human breastmilk is unknown
Pregnancy Categories:
Category A: Satisfactory and well-controlled studies show no risk to the fetus in the first or later trimester.
Category B: No evidence shown of risk to the fetus found in animal reproduction studies, and there are not enough studies on pregnant women
Category C: Adverse effects on the fetus found with evidence in animal reproduction studies and no adequate evidence for a result in humans must take care of potential risks in pregnant women
Category D: There is adequate data available with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits
Category X: Drugs listed in this category outweigh risks over benefits. Hence these categories of drugs need to be avoided by pregnant women.
Category N: There is no data available for the drug under this category
Patient Information Leaflet
Generic Name: entacapone (Rx)
Why do we use entacapone (Rx)?
entacapone (Rx) is an anti-Parkinson’s drug belonging to the subclass COMT inhibitors used to treat Parkinson’s disease
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Founded in 2014, medtigo is committed to providing high-quality, friendly physicians, transparent pricing, and a focus on building relationships and a lifestyle brand for medical professionals nationwide.
MASSACHUSETTS – USA
60 Roberts Drive, Suite 313,
North Adams, MA 01247
MAHARASHTRA – INDIA
7, Shree Krishna, 2nd Floor,
Opp Kiosk Koffee,
Shirole Lane, Off FC Road,
Pune 411004, Maharashtra
