DRUG INTERACTION

Contraindicated  

Serious Use Alternative  

Monitor Closely  

Minor  

Adverse drug reactions:   

Frequency defined:   

>10%  

Hyperkinesia  

Dyskinesia  

Nausea   

Diarrhea  

Urine discoloration   

1-10%  

Constipation   

Back pain   

Vomiting   

Dry mouth  

Hypokinesia  

Dizziness  

Abdominal pain  

Fatigue  

Dyspnea  

Increased sweating   

Agitation   

Gastritis   

Bacterial infection  

Flatulence   

Purpura  

Asthenia   

Hallucinations   

Taste perversion  

Frequency Not Defined  

Postural hypotension  

Confusion  

Insomnia  

  

Pregnancy warnings:     

US FDA pregnancy category: C 

Breastfeeding warnings:  

The release of the drug into the human breastmilk is unknown 

Pregnancy Categories:      

Category A: Satisfactory and well-controlled studies show no risk to the fetus in the first or later trimester.      

Category B: No evidence shown of risk to the fetus found in animal reproduction studies, and there are not enough studies on pregnant women      

Category C: Adverse effects on the fetus found with evidence in animal reproduction studies and no adequate evidence for a result in humans must take care of potential risks in pregnant women      

Category D: There is adequate data available with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits      

Category X: Drugs listed in this category outweigh risks over benefits. Hence these categories of drugs need to be avoided by pregnant women.      

Category N: There is no data available for the drug under this category

Patient Information Leaflet  

Generic Name: entacapone (Rx) 

 

Why do we use entacapone (Rx)? 

entacapone (Rx) is an anti-Parkinson’s drug belonging to the subclass COMT inhibitors used to treat Parkinson’s disease