epitiostanol

Action and Spectrum

Actions and Spectrum: 

Actions: 

Epitiostanol is bound to various androgen receptors on different sites, such as skeletal muscle tissues. This signaling begins a sequence of molecular reactions that end in synthesizing these proteins and the growth of muscle tissue.

Drug Interaction

Adverse Reaction

Adverse reaction

• Hirsutism
• Acne

Black Box Warning

Black Box Warning 

None

Contraindication / Caution

Contraindication/Caution: 

• Hypersensitivity
• Pregnancy and breast-feeding
• Liver dysfunction
• Prostate cancer

Pregnancy / Lactation

Pregnancy & breastfeeding:

Pregnancy consideration:  

No data is available regarding the administration of the drug during pregnancy.

Breastfeeding warnings:  

No data is available regarding the excretion of drugs in breast milk.

Pregnancy category: 

• Category A: well-controlled and satisfactory studies show no risk to the fetus in the first or later trimester.
• Category B: There was no evidence of risk to the fetus in animal studies, and there were not enough studies on pregnant women.
•  Category C: There was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.
•  Category D: Adequate data with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.
• Category X: Drugs listed in this category outweigh the risks over benefits. Hence, these categories of drugs need to be avoided by pregnant women.
• Category N: No data for the drug under this category is available.

Pharmacology

Pharmacology:

Androgen Receptor (AR) Agonism: Epitiostanol interacts with androgen receptors in many tissues (i.e., skeletal muscle and bones). It activates the transcription of genes involved in protein synthesis of muscle cells and bone tissue differentiation. This binding involves a complex mechanism that activates the androgen receptor, resulting in anabolic effects.

Pharmacokinetics: 

Absorption

The drug absorption occurs in the GI tract.

Distribution
After absorption, it can spread through the bloodstream leading to distribution of the drug throughout the body.

Metabolism

The drug metabolism occurs in the liver.

Excretion and Elimination

Major metabolites of epitiostanol are those that are excreted mainly through urine and the feces and the exact route of the metabolite excretion will be dependent on the final products of its metabolism.

Adminstartion

Administration: 

Individuals should discuss their need to use epitiostanol with a medical professional and it is vitally important also to consider risks and legal consequences.

The drug is taken orally.

Patient Information Leaflet

Patient information leaflet 

Generic Name: epitiostanol

Why do we use epitiostanol? 

Epitiostanol is widely known as an androgenic steroid, used mainly by bodybuilders to increase athletes’ strength and endurance. It works under the anabolic effect theory, helping individuals gain muscle and enhancing the user’s physical performance.

It could also be used as post-cycle therapy treatment to help restore natural testosterone production in a person at a level that is under control by the hypothalamic-pituitary-gonadal axis, which in turn mediates the process of testosterone production.