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Brand Name :
Longrange
Synonyms :
eprinomectin
Class :
Anti-parasitic, Anti-helmintic
Brand Name :
Longrange
Synonyms :
eprinomectin
Class :
Anti-parasitic, Anti-helmintic
Dosage Forms & Strengths
Extended-release injectable
5% sterile solution
Treatment and Long-Term Effectiveness of External and Internal Parasite Control in Pastured Cattle
:
Administer 1 mL/110 pounds of body weight
Each mL of longrange contains 50 mg of eprinomectin, which is enough to treat a person weighing 110 pounds. To prevent occasional pain or site response, divide dosages higher than 10 mL between two injection sites.
Dosage Forms & Strengths
Not to be used on dry dairy cows or any female dairy animals who are 20 months of aged or older.
Not to be used in calves that will be processed for veal.
Not to be used on calves younger than three months of age or for breeding bulls.
Not to be used with cattle kept under intense rotational grazing or in feedlots.
Refer adult dosing
Actions and Spectrum:
eprinomectin is a macrocyclic lactone anthelmintic, and it is a member of the avermectin/milbemycin class of compounds. This class of compounds is widely used in veterinary medicine to treat parasitic infections in animals.
Mechanism of Action:
Spectrum of Activity:
N/A
None
Contraindications/caution:
Pregnancy consideration: Insufficient data available
Lactation: Excretion of the drug in human breast milk is unknown
Pregnancy category:
Category A: well-controlled and Satisfactory studies show no risk to the fetus in the first or later trimester.
Category B: there was no evidence of risk to the fetus in animal studies, and there were not enough studies on pregnant women.
Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.
Category D: adequate data with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.
Category X: Drugs listed in this category outweigh the risks over benefits. Hence, these categories of drugs need to be avoided by pregnant women.
Category N: There is no data available for the drug under this category
Pharmacology:
eprinomectin is a macrocyclic lactone anthelmintic, belonging to the avermectin/milbemycin class of compounds. It is commonly used in veterinary medicine to treat parasitic infections in livestock, including gastrointestinal roundworms, lungworms, mites, and lice.
eprinomectin, like other macrocyclic lactones, exerts its anthelmintic (anti-parasitic) effects by binding to glutamate-gated chloride channels in the nerve and muscle cells of parasites. This binding leads to an increase in the permeability of the cell membrane to chloride ions, causing hyperpolarization and subsequent paralysis of the parasites. The paralysis ultimately results in the expulsion of the parasites from the host organism.
Spectrum of Activity:
Pharmacokinetics:
Absorption
eprinomectin is often administered to animals through topical or injectable routes.
When applied topically, it can be absorbed through the skin. Intramuscular or subcutaneous injection allows for direct absorption into the bloodstream.
Distribution
eprinomectin is lipophilic, meaning it has an affinity for fat tissues. It is distributed extensively in the body tissues. It can cross the blood-brain barrier, which contributes to its efficacy against parasites in the central nervous system.
Metabolism
eprinomectin undergoes hepatic metabolism. The metabolism involves the cytochrome P450 system in the liver.
Elimination and Excretion
eprinomectin and its metabolites are primarily excreted in the feces.
Administration:
Subcutaneous administration
To obtain the optimal route of administration, animals should be confined suitably. Utilizing a 16 or 18-gauge needle measuring ½ to ¾ inch, inject behind the loose tissue on the front of the shoulders.
Apply an appropriate disinfectant to the injection site. To limit the risk of injection site infections, use clean, fully cleaned needles.
Patient information leaflet
Generic Name: eprinomectin
Why do we use eprinomectin?
eprinomectin is a macrocyclic lactone anthelmintic widely used in veterinary medicine to control and treat parasitic infections in various animal species. Its primary use is against internal and external parasites.
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