Anthropometric Measurements as Predictors of Low Birth Weight Among Tanzanian Neonates: A Hospital-Based Study
November 7, 2025
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Brand Name :
Emcyt
Synonyms :
estramustine
Class :
Antineoplastics, Hormones
Brand Name :
Emcyt
Synonyms :
estramustine
Class :
Antineoplastics, Hormones
Dosage forms & Strengths:
Adult:
Tablet
100 mg
250 mg
Safety and efficacy are not seen in pediatrics
Tablet
100 mg
250 mg
estramustine: they may diminish the absorption of calcium salts
estramustine: they may diminish the absorption of calcium salts
estramustine: they may diminish the absorption of calcium salts
estramustine: they may diminish the absorption of calcium salts
estramustine: they may diminish the absorption of calcium salts
It may increase the serum concentration when combined with clodronate
Actions and Spectrum:
estramustine is a chemotherapy drug used to treat prostate cancer. It acts by binding to tubulin, a protein that helps in the formation of microtubules in cells.
estramustine interferes with the cell division process and can inhibit the growth of cancer cells. estramustine is primarily used to treat prostate cancer but has also been used in some cases of breast and endometrial cancer.
>10%:
Dyspnea
Edema
Diarrhea
Nausea
1-10%:
Insomnia
Lethargy
Myocardial infarction
Pulmonary embolism
Thrombophlebitis
Easy bruising
Leukopenia
Leg cramps
Decreased testosterone
Dry skin
Black Box Warning:
It is essential to follow the dosage and administration instructions for the medication carefully.
Contraindication/Caution:
Hypersensitivity: estramustine should not be used in individuals who are sensitive to the drug or any of its components.
Cardiovascular disease: Patients with a history of heart disease, stroke, or blood clots should use estramustine with caution.
Blood clotting disorders: estramustine may increase the risk of blood clots in individuals with clotting disorders.
Liver or kidney disease: Patients with liver or kidney disease may require dose adjustment or close monitoring of drug levels.
Pregnancy consideration:
Category X.
Breastfeeding warnings:
Not recommended for females.
Pregnancy category:
Category A: well-controlled and Satisfactory studies do not show risk to the fetus in the first/later trimester.
Category B: there was no evidence of risk to the fetus in animal studies, and there were not enough studies on pregnant women.
Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.
Category D: adequate data available with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.
Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women.
Category N: No data is available for the drug under this category.
Pharmacology
estramustine is an estradiol derivative that binds to tubulin, a protein involved in the formation of microtubules in cells. By binding to tubulin, estramustine interferes with the normal process of cell division, leading to the death of cancer cells. Additionally, estramustine has both estrogenic and anti-androgenic properties, which can help reduce the symptoms of prostate cancer.
Pharmacodynamics:
estramustine binds to tubulin, a protein involved in the formation of microtubules in cells. By binding to tubulin, estramustine interferes with the normal process of cell division, leading to the death of cancer cells.
estramustine has both estrogenic and anti-androgenic properties, which can help reduce the symptoms of prostate cancer.
estramustine has a high affinity for estrogen receptors and can bind to both alpha and beta subtypes.
Pharmacokinetics:
Pharmacokinetics studies how a drug is absorbed, distributed, metabolized, and eliminated by the body. The following parameters can describe the pharmacokinetics of estramustine.
Absorption
estramustine is absorbed in the gastrointestinal tract and reaches peak plasma levels approximately 2 hours after oral administration.
Distribution
estramustine is widely distributed throughout the body and can cross the blood-brain barrier.
Metabolism
estramustine is rapidly metabolized in the liver, primarily by the cytochrome P450 enzyme system.
Elimination and excretion
estramustine and its metabolites are primarily excreted in feces (2.9-4.8%).
Administration:
estramustine is administered orally as a capsule.
Patients should be regularly monitored while taking estramustine to assess for any adverse effects and to monitor the effectiveness of therapy. A healthcare provider should be notified immediately if any concerning symptoms or side effects occur while taking estramustine.
Patient information leaflet
Generic Name: estramustine
Pronounced: es-traa-mus-teen
Why do we use estramustine?
estramustine is used to treat prostate cancer.
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