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Brand Name :
Ethamolin
Synonyms :
ethanolamine oleate
Class :
Sclerosing Agents
Brand Name :
Ethamolin
Synonyms :
ethanolamine oleate
Class :
Sclerosing Agents
Dosage forms & Strengths:
Adult:
Solution for injection
50 mg/ml
Solution for injection
50 mg/ml
Refer to the adult dosing
Actions and Spectrum:
ethanolamine oleate is a phospholipid-based sclerosing agent used to treat varicose veins. Its actions include:
Vasoconstriction: ethanolamine oleate causes the veins to narrow, reducing blood flow and improving blood circulation.
Fibrosis: It promotes the formation of fibrous tissue within the veins. It causes them to become stiff and eventually disappear.
Frequency Not Defined:
Esophagitis
Fever
Reversible acute renal failure
Anaphylactic shock
Black Box Warning:
It is essential to follow the dosage and administration instructions for the medication carefully.
Contraindication/Caution:
Allergy: Patients who are hypersensitive to ethanolamine oleate should not use it.
Bleeding disorders: Patients with bleeding disorders or who take anticoagulants should use ethanolamine oleate cautiously.
Infection: Patients with active infections at the injection site should take ethanolamine oleate.
Deep vein thrombosis: ethanolamine oleate should not be used to treat deep vein thrombosis as it can cause embolization.
Arterial disease: ethanolamine oleate should be used with caution in patients with arterial disease as it may cause arterial occlusion.
Pregnancy consideration:
Category C.
Breastfeeding warnings:
Use with caution during breastfeeding.
Pregnancy category:
Category A: well-controlled and Satisfactory studies do not show risk to the fetus in the first/later trimester.
Category B: there was no evidence of risk to the fetus in animal studies, and there were not enough studies on pregnant women.
Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.
Category D: adequate data available with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.
Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women.
Category N: No data is available for the drug under this category.
Pharmacology
ethanolamine oleate is a sclerosing agent used in the treatment of varicose veins. It works by irritating the inner lining of the veins, which causes the collapse and seal shut of veins. The drug is injected directly into the affected vein and causes scarring, eventually resulting in the occlusion of the vein. ethanolamine oleate is considered a safe and effective treatment for varicose veins, although it can cause some side effects, including pain and swelling at the injection site.
Pharmacodynamics:
When injected into the affected vein, ethanolamine oleate irritates the vein’s inner lining, causing the smooth muscle cells to contract and the vein to collapse. This collapse triggers a series of events, including the release of growth factors and the activation of immune cells, which eventually result in fibrosis and occlusion of the vein.
Pharmacokinetics:
Pharmacokinetics studies how a drug is absorbed, distributed, metabolized, and eliminated by the body. The following parameters can describe the pharmacokinetics of ethanolamine oleate.
Absorption
The drug is not absorbed systemically.
Distribution
Not available
Metabolism
The drug does not undergo metabolism
Elimination and excretion
The drug is excreted majorly through the kidney and minorly in feces.
Administration:
ethanolamine oleate is administered intravenously.
Patient information leaflet
Generic Name: ethanolamine oleate
Pronounced: eth-a-nol-a-mine ol-ee-ate
Why do we use ethanolamine oleate?
ethanolamine oleate is used to treat bleeding esophageal varices.
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