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Brand Name :
ethamide, diuretic C
Synonyms :
ethoxzolamide
Class :
carbonic anhydrase inhibitors, diuretics
Brand Name :
ethamide, diuretic C
Synonyms :
ethoxzolamide
Class :
carbonic anhydrase inhibitors, diuretics
 Dosage Forms & Strengths  Â
Tablet  Â
62.5 mgÂ
125 mÂ
Administer 62.5mg tablet orally twice a day
Dosage Forms & StrengthsÂ
Safety and efficacy not establishedÂ
Refer adult dosingÂ
Actions and Spectrum:Â
It works by the inhibition of carbonic anhydrase enzyme that helps to transport H+ and CO2 into the extracellular and intracellular spaces.Â
Frequency not defined  Â
DiarrheaÂ
VomitingÂ
FatigueÂ
ParesthesiaÂ
leg cramps Â
Black box warning:Â Â Â
None Â
 Â
Contraindications/caution:Â Â Â
Contraindications:Â Â Â
Pregnancy Warnings:Â
Pregnancy category: Insufficient data available  Â
Lactation: Excretion of drug in human breast milk is unknownÂ
Pregnancy Categories:Â Â Â
Category A: Satisfactory and well-controlled studies show no evidence of risk to the fetus in the first trimester or in the later trimester.  Â
Category B: No evidence of risk to fetus found in animal reproduction studies and there are not enough studies on pregnant women.  Â
Category C: Adverse effects on the fetus found with evidence in animal reproduction studies and no adequate evidence for an effect in humans, care must be taken for potential risks in pregnant women.  Â
Category D: There is adequate data available with sufficient evidence of human fetal risk from various platforms, but despite potential risks may be used only in emergency cases for potential benefits.  Â
Category X: Drugs listed in this category clearly outweigh risks over benefits. These category drugs should be prohibited for pregnant women.  Â
Category N: There is no data available for the drug under this category.   Â
Pharmacology:Â Â Â
It inhibits the enzyme carbonic anhydrase, which plays a role in H+ and CO2 ion transport into the extra and intracellular spaces.Â
Pharmacodynamics:Â Â Â Â
ethaoxzolamide is a carbonic anhydrase inhibitor that decreases the carbonic anhydrase activity in CNS. The carbonic anhydrase inhibition in the eye may decrease the intraocular pressure and decrease aqueous humour. Â
Pharmacokinetics:Â Â Â
AbsorptionÂ
the drugs is rapidly absorded with a bioavailability of 65%. Protein binding of 89%.Â
DistributionÂ
It has large volume of distribution throughout the body including eyes and kidneys.Â
MetabolismÂ
It involves hepatic metabolism through CYP1A2 enzyme.Â
Elimination and ExcretionÂ
The drug is excreted renally. The elimination half life is 2.5-5.5 hoursÂ
AdministrationÂ
It is taken orally after the meals.Â
Patient information leaflet  Â
Generic Name: ethoxzolamide Â
Pronounced: (eth-oxo-zol-am-ide)Â
Why do we use ethoxzolamide?  Â
ethoxzolamide is used to treat duodenal ulcers, glaucoma and epiplepsy. Â
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