felbinac

Action and Spectrum

Actions and spectrum: 

• Anti-Inflammatory Effects: Felbinac exerts its anti-inflammatory effects by inhibiting the enzyme cyclooxygenase (COX). COX is involved in the synthesis of prostaglandins, which are mediators of inflammation. By inhibiting COX, felbinac reduces the production of prostaglandins and, consequently, decreases inflammation. Felbinac is primarily used as a topical medication, often in the form of a gel or cream. This allows for localized treatment of pain and inflammation. Felbinac is commonly used to relieve pain and inflammation associated with osteoarthritis, rheumatoid arthritis, and musculoskeletal disorders. It may also be used in the management of pain and inflammation following traumatic injuries or surgical procedures. 
• Spectrum of Activity: Felbinac’s spectrum of activity is related to its anti-inflammatory and analgesic effects. It is not a broad-spectrum antibiotic or antiviral medication; rather, it is targeted at reducing inflammation and relieving pain in the specific areas where it is applied. 

Drug Interaction

Adverse Reaction

Frequency not defined 

Asthma 

Paraesthesia 

dyspepsia 

dyspnoea 

Pruritus 

dermatitis 

purpura 

erythema multiforme 

application site reaction 

renal disease 

GI disturbance 

Bronchospasm 

Wheezing 

rash 

angioedema 

epidermal necrolysis 

photosensitivity 

Black Box Warning

Black Box Warning: 

there may not have been any specific black box warning for felbinac. 

Contraindication / Caution

Contraindication/Caution: 

Contraindication: 

• Hypersensitivity or Allergy: Individuals with known hypersensitivity or allergy to felbinac or any of its components should not use the medication. 
• History of Asthma, Allergic Reactions, or Respiratory Issues: NSAIDs, including felbinac, may exacerbate asthma symptoms or cause allergic reactions in some individuals. Therefore, it may be contraindicated in individuals with a history of asthma, allergic reactions, or respiratory issues related to NSAIDs. 
• Severe Renal Impairment: NSAIDs, including felbinac, can have effects on renal function. It may be contraindicated in individuals with severe renal impairment or those at risk of renal failure. 
• Severe Heart Failure: NSAIDs can cause fluid retention and edema, which may be problematic in individuals with severe heart failure. Felbinac may be contraindicated in such cases.

Caution: 

• Renal Impairment: NSAIDs can have effects on renal function, and their use may be associated with kidney problems. Caution is advised in individuals with pre-existing renal impairment or those at risk of renal dysfunction. 
• Gastrointestinal Effects: NSAIDs, including felbinac, can increase the risk of gastrointestinal ulcers and bleeding. Individuals with a history of gastrointestinal issues or those taking medications that may increase the risk of gastrointestinal bleeding should use felbinac with caution. 
• Asthma and Respiratory Conditions: NSAIDs, including felbinac, may exacerbate asthma symptoms or cause respiratory reactions in some individuals. Caution is advised in individuals with a history of asthma or other respiratory conditions. 
• Hypertension: Felbinac may cause an increase in blood pressure. Caution is recommended in individuals with hypertension or uncontrolled high blood pressure. 
• Skin Sensitivity: Topical medications like felbinac can sometimes cause skin irritation or sensitization. Caution is recommended in individuals with a history of skin reactions to medications.

Comorbidities: 

• Cardiovascular Disease: NSAIDs, including felbinac, may be associated with an increased risk of heart attack. Individuals with a history of cardiovascular disease should use felbinac with caution, and the benefits and risks should be carefully evaluated. 
• Hypertension: Felbinac may cause an increase in blood pressure. Individuals with hypertension or those at risk of high blood pressure should be monitored. 
• Renal Impairment: NSAIDs can have adverse effects on renal function, and their use may be associated with kidney problems. Individuals with pre-existing renal impairment or those at risk of renal dysfunction should use felbinac with caution. 
• Gastrointestinal Conditions: NSAIDs, including felbinac, can increase the risk of gastrointestinal ulcers and bleeding. Individuals with peptic ulcers, gastrointestinal bleeding, or other digestive system disorders should use felbinac cautiously, and their gastrointestinal health should be monitored. 
• Asthma and Respiratory Conditions: NSAIDs, including felbinac, may exacerbate asthma symptoms or cause respiratory reactions in some individuals. Caution is advised in individuals with a history of asthma or other respiratory conditions. 

Pregnancy / Lactation

Pregnancy consideration: pregnancy category: not assigned 

Lactation: excreted into human milk: unknown  

Pregnancy category: 

• Category A: well-controlled and Satisfactory studies show no risk to the fetus in the first or later trimester. 
• Category B: there was no evidence of risk to the fetus in animal studies, and there were not enough studies on pregnant women. 
• Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.   
• Category D: adequate data with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits. 
• Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women. 
• Category N: There is no data available for the drug under this category. 

Pharmacology

Pharmacology: 

Felbinac is a nonsteroidal anti-inflammatory drug (NSAID) with pharmacological properties that make it effective in managing pain and inflammation. As a topical medication, felbinac is applied locally, allowing for targeted relief. It exerts its effects by inhibiting cyclooxygenase (COX), which plays a role in production of prostaglandins—molecules that mediate inflammation and pain.

By blocking COX, felbinac reduces the synthesis of prostaglandins, leading to a decrease in inflammation and providing analgesic effects. This mechanism of action makes felbinac particularly suitable for conditions like osteoarthritis and rheumatoid arthritis, as well as for alleviating pain associated with musculoskeletal injuries or surgical procedures.

The localized application minimizes systemic exposure, reducing the risk of certain systemic side effects often associated with oral NSAIDs. While felbinac can be an effective option for managing pain and inflammation, its use should be approached cautiously in individuals with specific contraindications or comorbidities, and it is essential to adhere to prescribed dosages and guidelines for optimal safety and efficacy.  

Pharmacodynamics: 

• Inhibition of Cyclooxygenase (COX): Felbinac inhibits the activity of the enzyme cyclooxygenase (COX), particularly the COX-1 and COX-2 isoforms. COX converts arachidonic acid into prostaglandins, which are mediators of inflammation, pain, and fever. By inhibiting COX, felbinac reduces the production of prostaglandins, leading to decreased inflammation and pain. 
• Reduction of Prostaglandin Synthesis: Prostaglandins play a key role in the inflammatory response by promoting vasodilation, increasing capillary permeability, and sensitizing pain receptors. Felbinac’s inhibition of COX results in decreased prostaglandin synthesis, thereby mitigating these inflammatory responses. 
• Anti-Inflammatory Effects: The reduction in prostaglandin levels contributes to the anti-inflammatory effects of felbinac. This is particularly relevant in conditions such as osteoarthritis and rheumatoid arthritis, where inflammation is a significant component of the pathology. 
• Analgesic (Pain-Relieving) Effects: Felbinac’s analgesic effects are achieved through its ability to modulate pain pathways by decreasing the production of prostaglandins, which sensitize pain receptors and contribute to perception of pain.

Pharmacokinetics: 

• Absorption: Felbinac is primarily administered topically, usually in the form of gels or creams. This topical application allows for local absorption through the skin. Felbinac is absorbed through the skin, providing localized effects at the site of application. This helps minimize systemic absorption, reducing the risk of systemic side effects common with oral NSAIDs. 
• Distribution: After absorption through the skin, felbinac is distributed to the local tissues and may enter the systemic circulation. The distribution is limited to the area where it is applied, resulting in targeted effects. 
• Metabolism: Felbinac undergoes hepatic (liver) metabolism. The specific metabolic pathways and metabolites of felbinac may vary among individuals. The liver enzymes may be involved in the biotransformation of felbinac into metabolites. 
• Excretion: The primary route of excretion for felbinac and its metabolites is through the kidneys. Renal excretion is crucial for eliminating the drug from the body. 

Adminstartion

Administration: 

• Clean the Skin: Before applying felbinac, clean the skin at the intended application site. Use mild soap and water, and ensure that the area is dry before applying the medication. 
• Dosage and Frequency: Follow the specific dosage and frequency depending on the severity of condition and the specific formulation of felbinac. 
• Application to Affected Area: Apply a sufficient amount of felbinac gel or cream to cover the entire area where you are experiencing pain or inflammation. 
• Wash Hands: Wash your hands after applying felbinac to prevent unintentional transfer of the medication to other areas or surfaces. 
• Avoid Sun Exposure: In some cases, it may be advisable to avoid excessive sun exposure or use protective measures, as certain topical medications, including felbinac, can increase sensitivity to sunlight. 

Patient Information Leaflet

Patient information leaflet 

Generic Name: felbinac 

Pronounced: (FEL-bin-ak) 

Why do we use felbinac? 

Felbinac is a nonsteroidal anti-inflammatory drug (NSAID) that is primarily used topically for its anti-inflammatory and analgesic properties. Felbinac is often prescribed for the topical treatment of osteoarthritis, a degenerative joint disease. In rheumatoid arthritis, an autoimmune condition causing joint inflammation, felbinac may be used topically to provide relief from pain and inflammation.

Felbinac may be prescribed for various musculoskeletal disorders, including conditions such as tendonitis or bursitis, where localized anti-inflammatory and analgesic effects are beneficial. Felbinac is suitable for providing localized pain relief in areas where inflammation is present. This targeted approach minimizes systemic exposure and reduces the side effects associated with oral NSAIDs. It may be used in the management of pain associated with specific conditions or injuries, such as sprains, strains, or sports-related injuries.