- March 15, 2022
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Brand Name :
Plendil
Synonyms :
felodipine
Class :
Calcium channel blockers and antihypertensives
Dosage Forms & Strengths
Tablet extended release, Oral:
2.5 mg
5 mg
10 mg
initial dose:
5
mg
Orally
once a day
Maintenance dose: 10 mg orally once a day after 2 to 4 weeks of the initial dose
2.5 - 5
mg
Orally
once a day
1 - 2
weeks
Dosage Forms & Strengths
Tablet extended release, Oral:
2.5 mg
5 mg
10 mg
For children > 5 years:
2.5 - 5
mg
Orally
once a day
1 - 2
weeks
Refer to adult dosing
felodipine: they may diminish the serum concentration of CYP3A4 Inducers
felodipine: they may diminish the serum concentration of CYP3A4 Inducers
felodipine: they may diminish the serum concentration of CYP3A4 Inducers
felodipine: they may diminish the serum concentration of CYP3A4 Inducers
felodipine: they may diminish the serum concentration of CYP3A4 Inducers
It may enhance toxicity when combined with cholic acid by diminishing the elimination
CYP3A strong enhancers of the small intestine may reduce the bioavailability of felodipine
It may enhance the serum concentration when combined with CYP3A4 Inhibitors (Moderate)
It may enhance the serum concentration when combined with CYP3A4 Inhibitors (Moderate)
It may enhance the serum concentration when combined with CYP3A4 Inhibitors (Moderate)
It may enhance the serum concentration when combined with CYP3A4 Inhibitors (Moderate)
It may enhance the serum concentration when combined with CYP3A4 Inhibitors (Moderate)
It may diminish the effects when combined with metformin by pharmacodynamic antagonism
the effect of felodipine is decreased by lorlatinib, by altering intestinal or hepatic CYP3A4 enzyme metabolism
relugolix/estradiol/norethindrone
may increase the level of effectiveness through P-glycoprotein MDR1 efflux transporter
Frequency defined:
>10%
Peripheral edema
Headache
1% to 10%
Flushing
Tachycardia
<1% Postmarketing
Abdominal pain
Acid regulation
Anemia
Bruise
Chest pain
Pregnancy consideration: Not enough studies are available for felodipine, therefore not recommended as initial therapy in pregnant women. Some adverse effects were reported in animal reproductive studies.
Lactation: excretion of felodipine in breast milk is not known.
Pregnancy category:
Patient information leaflet
Generic Name: Felodipine
Pronounced: felodipine
Why do we use felodipine?
Felodipine is used for the treatment of hypertension and Chronic angina.
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