Brand Name :
Corlopam
Synonyms :
fenoldopam
Class :
Vasodilators; Endocrine, Dopamine Agonists
Brand Name :
Corlopam
Synonyms :
fenoldopam
Class :
Vasodilators; Endocrine, Dopamine Agonists
Dosage forms & Strengths:
Adult:
Injectable solution
10 mg/ml
Injectable solution
10 mg/ml
Refer to the adult dosing
Actions and Spectrum:
fenoldopam is a medication that belongs to a class of drugs called dopamine agonists. It works by stimulating dopamine receptors in the body, specifically the D1-like receptors in the renal, mesenteric, and coronary vessels. This leads to vasodilation of these blood vessels, which in turn can help to lower blood pressure.
Frequency undefined:
Angina
Dizziness
Flushing
Hypotension
Myocardial infarction
Tachycardia
Nausea
Vomiting
Increased serum creatinine
Black Box Warning:
It is essential to follow the dosage and administration instructions for fenoldopam carefully.
Contraindication/Caution:
fenoldopam should not be used in people hypersensitive to the drug itself.
Pregnancy consideration:
Limited data is available regarding the use of febuxostat in pregnant women.
Breastfeeding warnings:
No data is available regarding the presence of drugs in human breast milk.
Pregnancy category:
Pharmacology
fenoldopam is highly selective for D1 receptors, which are found in renal, mesenteric, and coronary vessels. D1 receptor stimulation by fenoldopam leads to renal vasodilation, which leads to an increase in renal blood flow and glomerular filtration rate, which, in turn, improves renal function in patients with renal impairment.
fenoldopam has been shown to be an effective antihypertensive medication in clinical trials. It has been shown to lower blood pressure in patients with hypertension and to improve renal function in patients with renal impairment.
Pharmacodynamics:
The main mechanism of action of fenoldopam is as a selective dopamine D1 receptor agonist. Dopamine is a neurotransmitter that is involved in the regulation of blood pressure. When fenoldopam binds to the dopamine D1 receptors in the kidneys, it causes an increase in the activity of the enzyme renin-angiotensin-aldosterone system (RAAS). It leads to increased blood flow and decreased sodium reabsorption in the kidneys. This, in turn, results in a decrease in blood pressure.
Pharmacokinetics:
fenoldopam is administered intravenously (IV) and has a rapid onset of action, typically within minutes of administration. It has a relatively short half-life of about 5 minutes. The volume of distribution is 0.6 L/kg
Absorption
After being administered, it is rapidly absorbed into the bloodstream. The peak concentration of the drug in the bloodstream typically occurs within 2 to 5 minutes. The absorption of fenoldopam is not affected by food.
Distribution
The volume of distribution of fenoldopam is 0.6L/kg
Metabolism
fenoldopam is metabolized in the liver to various sulfates, glucuronide, and methoxy metabolites.
Elimination and excretion
The drug is excreted in urine and feces in the ratio; 9:1.
Administration:
fenoldopam is administered through an intravenous route. It is used in the form of a diluted solution to be used within 24 hours
Patient information leaflet
Generic Name: fenoldopam
Pronounced: fe-NOL-doe-pam
Why do we use fenoldopam?
fenoldopam helps to treat severe or malignant hypertension.