ferrous bisglycinate

Action and Spectrum

Actions and Spectrum: 

Actions: 

As an additional type of iron, ferrous bisglycinate gives the body an external supply of this necessary element. Ferrous bisglycinate promotes the effective transport of oxygen in the bloodstream, assisting in the supply of oxygen to cells and tissues by promoting the synthesis of haemoglobin. 

Spectrum: 

As a source of elemental iron, ferrous bisglycinate helps the body rebuild its iron reserves. Ferrous bisglycinate’s main function is to aid in the manufacture of haemoglobin, which is an essential part of red blood cells and is in charge of carrying oxygen. 

Drug Interaction

Adverse Reaction

Frequency not defined 

Low BP 

Rash 

Dyspnea 

Dizziness 

Swelling 

Itching 

Black Box Warning

Black Box Warning: 

See a doctor right away if you experience any allergic reaction symptoms.

Contraindication / Caution

Contraindication/Caution: 

Contraindications 

• Hypersensitivity 

Cautions 

• IBD 
• Hemochromatosis (hereditary) 
• Renal impairment 
• Hepatic impairment 
• Drug interactions 
• Pregnancy  
• Breastfeeding 

Pregnancy / Lactation

Pregnancy consideration:  

No data is available regarding the administration of the drug during pregnancy. 

Breastfeeding warnings:  

No data is available regarding the excretion of drug in breast milk. 

Pregnancy category: 

Category A: well-controlled and satisfactory studies show no risk to the fetus in the first or later trimester. 

Category B: there was no evidence of risk to the fetus in animal studies, and there were not enough studies on pregnant women. 

Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.    

Category D: adequate data with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.    

Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women.    

Category N: No data is available for the drug under this category. 

Pharmacology

Pharmacology: 

A key application of ferrous bisglycinate in therapy involves preventing and treating conditions related to insufficient iron levels, such as iron deficiency and iron deficiency anemia. Causes of iron deficiency may stem from factors such as insufficient dietary intake, challenges in absorption, or heightened iron needs. 

Pharmacodynamics: 

Ferrous bis-glycinate serves as a provider of elemental iron. Upon ingestion, its chelation with glycine enhances absorption in the gastrointestinal tract, resulting in heightened iron bioavailability compared to certain other iron supplements. Iron plays a pivotal role in hemoglobin, the protein accountable for transporting oxygen within red blood cells.

Ferrous bis-glycinate aids in hemoglobin synthesis, thereby playing a role in the creation of functional red blood cells. Through its involvement in hemoglobin synthesis, ferrous bis-glycinate assists in the binding and transport of oxygen to tissues throughout the body via the lungs. Iron, which is not immediately utilized in hemoglobin synthesis, is stored as ferritin. Ferrous bis-glycinate actively contributes to ferritin formation, thus aiding in the maintenance of iron reserves within the body. 

Pharmacokinetics: 

Absorption 

Ferrous bis-glycinate undergoes absorption in the small intestine, primarily in the duodenum and upper jejunum. Its chelation with glycine serves to improve absorption in comparison to other forms of iron supplements. 

Distribution 

Following absorption, iron is derived from ferrous bis-glycinate via the bloodstream and is carried throughout the body bound to transferrin. This iron is distributed to various tissues, and a substantial portion is stored in the liver, spleen, and bone marrow. 

Metabolism 

Iron experiences minimal metabolism within the body. The design of the chelated iron form in ferrous bis-glycinate facilitates ready absorption, necessitating less conversion or modification in the metabolic process. 

Elimination and Excretion 

Under normal circumstances, iron is not actively excreted from the body. Instead, iron turnover occurs as part of the body’s physiological processes. Excess iron may either be stored or lost through mechanisms such as the shedding of skin and mucosal cells. 

Adminstartion

Administration: 

Ferrous bisglycinate is suitable for consumption with or without food. However, pairing it with vitamin C-rich foods or beverages can boost iron absorption by leveraging heightened stomach acidity. It’s essential to maintain consistency in the timing and method of administration. Taking ferrous bisglycinate at a consistent daily time contributes to sustaining a stable iron level in the body.

Always stick to the dosage and administration guidelines outlined by your healthcare provider or specified on the product label. Given that individual requirements differ, healthcare professionals take into account factors like age, gender, and specific health conditions when recommending iron supplements. 

Patient Information Leaflet

Patient information leaflet 

Generic Name: ferrous bisglycinate 

Pronounced: Fer-us bis-gly-sin-ate 

Why do we use ferrous bisglycinate?  

A primary application of ferrous bisglycinate involves addressing iron deficiency anemia, a condition that emerges when the body lacks sufficient iron to generate an ample amount of hemoglobin. This insufficiency results in a reduced ability to transport oxygen in the bloodstream.

Ferrous bisglycinate is selected for its heightened bioavailability in comparison to certain other iron supplements. The chelation process with glycine enhances absorption in the gastrointestinal tract, rendering it a more effective source of absorbable iron.