Anthropometric Measurements as Predictors of Low Birth Weight Among Tanzanian Neonates: A Hospital-Based Study
November 7, 2025
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Brand Name :
Evicel, Tisseel VH, Artiss, TachoSil
Synonyms :
fibrin sealant
Class :
Hemostatics, Wound Care
Brand Name :
Evicel, Tisseel VH, Artiss, TachoSil
Synonyms :
fibrin sealant
Class :
Hemostatics, Wound Care
Dosage Forms & StrengthsÂ
KitÂ
55 to 85 mg/ml fibrinogen and 800 units/ml thrombin Â
67 to 106 mg/ml fibrinogen and 2.5 to 6.5 units/ml thrombin Â
67 to 106 mg/ml fibrinogen and 400 to 625 units/ml thrombin Â
PatchÂ
3.6 to 7.4 mg/cm² fibrinogen and 1.3 to 2.7 units/cm² Â
For Evicel
Spray onto the surface of bleeding tissues in brief bursts about 0.1 to 0.2 ml and if the hemostatic outcome is incomplete then apply a another coat
If the maximum area to be sealed is 20 cm², then use around 2 ml
If the maximum area to be sealed is 40 cm², then use around 4 ml
If the maximum area to be sealed is 100 cm², then use around 10 ml
For TachoSil Patch
If not more than 7 patches are to be applied, then apply patch size of about 9.5 cm x 4.8 cm
If not more than 14 patches are to be applied, then apply patch size of about 4.8 cm x 4.8 cm
If not more than 42 patches are to be applied, then apply patch size of about 3.0 cm x 2.5 cm
For Tisseel VH
If the maximum area to be sealed is 8 cm² through a cannula then use around 2 ml
If the maximum area to be sealed is 16 cm² through a cannula then use around 4 ml
If the maximum area to be sealed is 40 cm² through a cannula then use around 10 ml
Autologous Skin Graft AdherenceÂ
If the graft fixation area is 100 cm², then use around 2 ml
If the graft fixation area is 200 cm², then use around 4 ml
If the graft fixation area is 500 cm², then use around 10 ml
Dosage Forms & StrengthsÂ
KitÂ
55 to 85 mg/ml fibrinogen and 800 units/ml thrombin Â
67 to 106 mg/ml fibrinogen and 2.5 to 6.5 units/ml thrombinÂ
67 to 106 mg/ml fibrinogen and 400 to 625 units/ml thrombin Â
For Evicel
Safety and efficacy not determined in less than six years old
≥6 months:
Spray onto the surface of bleeding tissues in brief bursts about 0.1 to 0.2 ml and if the hemostatic outcome is incomplete then apply a another coat
If the maximum area to be sealed is 20 cm², then use around 2 ml
If the maximum area to be sealed is 20 cm², then use around 2 ml
If the maximum area to be sealed is 40 cm², then use around 4 ml
If the maximum area to be sealed is 100 cm², then use around 10 ml
For Tisseel
For <1 month: Safety and efficacy not determined
For ≥1 month:
If the maximum area to be sealed is 8 cm² through a cannula then use around 2 ml
If the maximum area to be sealed is 16 cm² through a cannula then use around 4 ml
If the maximum area to be sealed is 40 cm² through a cannula then use around 10 ml
Autologous Skin Graft AdherenceÂ
Safety and efficacy not determined in less than one year old
If the graft fixation area is 100 cm², then use around 2 ml
If the graft fixation area is 200 cm², then use around 4 ml
If the graft fixation area is 500 cm², then use around 10 ml
Refer to adult dosingÂ
Actions and SpectrumÂ
fibrin sealant is generally composed of two main components like fibrinogen and thrombin. When these components are mixed, they initiate a cascade of biochemical reactions that result in the formation of a fibrin clot.Â
Frequency not defined Â
PruritusÂ
Abdominal pain Â
Anemia Â
Pleural effusionÂ
Increased serum fibrinogenÂ
Atrial fibrillationÂ
HematomaÂ
Postoperative hemorrhageÂ
Graft complications Â
AscitesÂ
Nervous system: HeadacheÂ
Deep vein thrombosisÂ
Antibody developmentÂ
Pulmonary embolismÂ
Gastrointestinal hemorrhageÂ
Abdominal distensionÂ
Ischemic bowel diseaseÂ
Abscess Â
Peritoneal effusionÂ
Post marketing reportsÂ
Hematologic and oncologic: EosinophiliaÂ
Hypersensitivity: Anaphylactic shock, anaphylaxis, nonimmune anaphylaxis, angioedema, hypersensitivity reaction Â
Respiratory: Bronchospasm, respiratory distress, dyspnea, hemothorax, laryngeal edema, wheezingÂ
Cardiovascular: Bradycardia, tachycardia, thrombosis, embolism, flushing, hypotension, Â
Dermatologic: Erythema of skin, urticariaÂ
Gastrointestinal: Intestinal obstruction, gastrointestinal scarringÂ
Nervous system: Cerebral artery embolism, paresthesia, nerve compressionÂ
Renal: Renal artery thrombosis, renal failure syndromeÂ
Black Box WarningÂ
None
Contraindication/Caution:Â
Contraindication:Â
Caution:Â
Pregnancy consideration:Â
Pregnancy category: CÂ
Lactation: Excretion into human milk is unknown Â
Pregnancy Categories:        Â
Category A: well-controlled and Satisfactory studies show no risk to the fetus in the first or later trimester.Â
Category B: there was no evidence of risk to the fetus in animal studies, and there were not enough studies on pregnant women. Â
Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.Â
Category D: adequate data with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.Â
Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women.Â
Category N: There is no data available for the drug under this category.Â
Pharmacology Â
fibrinogen is a protein found in the blood plasma. It is synthesized in the liver and circulates in an inactive form. Â
The formed fibrin clot adheres to the surrounding tissues, providing a mechanical barrier and promoting hemostasis by stopping bleeding.Â
PharmacodynamicsÂ
fibrin sealant promotes hemostasis by forming a fibrin clot at the site of application. Â
fibrin sealant acts as a tissue adhesive, facilitating the adhesion and bonding of biological tissues. Â
Pharmacokinetics Â
Limited information available on ADMEÂ Â
AdministrationÂ
fibrin sealant is administered topically or locally at the site of application. e.g., surgical wounds.Â
Patient information leafletÂ
Generic Name: fibrin sealantÂ
Why do we use fibrin sealant?Â
fibrin sealant acts as a tissue adhesive, helping to bond and secure tissues together. Â
fibrin sealant is used to promote hemostasis i.e., stop bleeding in surgical procedures or traumatic injuries.  Â
fibrin sealant is used to support tissue grafts and flaps in reconstructive surgeries.
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