fludarabine

Action and Spectrum

Drug Interaction

Adverse Reaction

>10%: 

Fever  

Objective weakness  

Anemia  

Neutropenia  

Thrombocytopenia  

Leukopenia  

Cough  

Pain  

Fatigue  

Anorexia  

Malaise  

Dyspnea  

Pneumonia  

Edema  

Myalgia 

UTI  

Rash 

Diarrhea  

Visual disturbances  

Diaphoresis  

GI bleeding  

Paresthesia 

1-10%: 

Abdominal pain  

Back pain 

Headache  

Pharyngitis 

Stomatitis  

Flu-like syndrome  

Malaise  

Angina  

Hearing Loss 

Peripheral edema  

Alopecia  

Constipation  

Arrhythmia 

Black Box Warning

Contraindication / Caution

Fludarabine is contraindicated in patients hypersensitive to the formulation’s active ingredient and other excipients. 

Pregnancy / Lactation

Pregnancy consideration:  

Category D. 

Breastfeeding warnings:  

It is not known if the drug is excreted in the breast milk. 

Pregnancy category: 

• Category A: well-controlled and Satisfactory studies do not show risk to the fetus in the first/later trimester.        
• Category B: there was no evidence of risk to the fetus in animal studies, and there were not enough studies on pregnant women        
• Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.       
• Category D: adequate data available with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.        
• Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women.        
• Category N: There is no data available for the drug under this category 

Pharmacology

Adminstartion

Patient Information Leaflet

Patient information leaflet 

Generic Name: fludarabine 

Pronounced: flu-dar-a-bine 

Why do we use fludarabine? 

Fludarabine belongs to the category of antineoplastics. It helps to treat B-Cell Chronic Lymphocytic Leukemia.