Mechanism of action
The mechanism of action of fludrocortisone involves binding to the mineralocorticoid receptor in the kidney, leading to an increase in the activity of the sodium-potassium ATPase pump. This, in turn, increases sodium reabsorption and potassium excretion, increasing blood volume and blood pressure.
Spectrum
The spectrum of activity of fludrocortisone includes treating conditions that result from a lack of adequate amounts of aldosterone, such as adrenal insufficiency (Addison’s disease) and hypoaldosteronism (low levels of aldosterone). It is also used in the treatment of salt-losing adrenogenital syndrome and as a component of replacement therapy in congenital adrenal hyperplasia.
