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Brand Name :
Locorten Vioform (U.K) Locacorten Vioform (Canada)
Synonyms :
flumetasone pivalate/ clioquinol
Class :
corticosteroids
Brand Name :
Locorten Vioform (U.K) Locacorten Vioform (Canada)
Synonyms :
flumetasone pivalate/ clioquinol
Class :
corticosteroids
Dosage Forms & Strengths
Solutions (Ear drops)
Flumetasone pivalate- 0.02% w/v
Clioquinol- 1% w/v
Creams (External application)
Flumetasone- 0.02%
Clioquinol- %
The recommended dosage is 2 to 3 drops 2 times a day for 7 to 10 days
Dosage Forms & Strengths
Solutions (Ear drops)
Flumetasone pivalate- 0.02% w/v
Clioquinol- 1% w/v
Creams (External application)
Flumetasone- 0.02%
Clioquinol- %
For use in children above two years of age:
Refer to adult dosing
Actions and spectrum:
Flumetasone Pivalate is a member of the corticosteroid class. It possesses vasoconstrictive, anti-inflammatory, and anti-pruritic abilities. It also reduces the migration of polymorphonuclear leukocytes and reverses capillary permeability to inhibit the inflammatory response. Clioquinol exhibits both antibacterial and antifungal abilities. It kills microorganisms by interfering with their ability to divide and function.
Frequency not defined
Burning
Irritation of the skin
Atrophy of skin
Difficulty breathing
Swelling of throat, face, or lips
Hypertrichosis
Skin pigmentation
Telangiectasia
Changes in hair color
Adrenal suppression on prolonged use
Raised risk of cataract
Black Box Warning
Contact the doctor immediately if ear drops are swallowed accidentally
Contraindication/Caution:
Contraindication:
Hypersensitivity
Anti-infective therapy
Iodine sensitivity
Kaposi’s sarcoma
Peripheral neuropathy
Optic atrophy
Pregnancy consideration:
Caution is recommended
Lactation:
It is not recommended. If necessary, take the advice of the physician before using it.
Pregnancy category:
Category A: Studies that were well-controlled and met expectations revealed no risk to the fetus `in either the first or second trimester.
Category B: There were a lack of studies on pregnant women and no evidence of risk to the fetus in animal experiments.
Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.
Category D: adequate data with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.
Category X: Drugs listed in this category outweigh the risks over benefits. Hence, these categories of drugs need to be avoided by pregnant women.
Category N: There is no data available for the drug under this category
Pharmacology:
Pharmacodynamics:
Flumetasone pivalate is a moderately potent glucocorticoid. It has anti-allergic, anti-inflammatory, vasoconstrictive, and anti-proliferative properties. Clioquinol is a derivative of halogenated hydroxyquinoline that functions as a bacteriostatic agent by chelating trace metals and bacterial surfaces that are necessary for bacterial growth.
Pharmacokinetics:
Absorption
Approximately 1.5-4% of clioquinol is absorbed
Distribution
Metabolism
Elimination and excretion
Clioquinol is mainly excreted through urine as glucuronide and as sulfates in smaller amounts
Half-life:
Administration:
With the affected ear up top, sit or lie down.
Squeeze the middle of the bottle with your fingers after placing the bottle’s nozzle close to the ear opening.
Keep your head tilted for a few minutes. To prevent any drops from running out, briefly insert a piece of loose cotton wool into the ear opening.
Take great care to avoid getting ear drops in or close to the eyes.
Once the ear drop has been applied, wash your hands.
Patient information leaflet
Generic Name: flumetasone pivalate/ clioquinol
Why do we use flumetasone pivalate/ clioquinol?
Flumetasone pivalate/ clioquinol is used in the treatment of infection and inflammation of the external ear. The combination of flumetasone pivalate/clioquinol possesses antifungal and antibacterial activity.
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