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Brand Name :
Flarex, FML, FML Forte
Synonyms :
fluorometholone
Class :
Antivirals, Corticosteroids, Ophthalmic, Ophthalmic
Brand Name :
Flarex, FML, FML Forte
Synonyms :
fluorometholone
Class :
Antivirals, Corticosteroids, Ophthalmic, Ophthalmic
Dosage Forms & Strengths
ophthalmic suspension (in base form)
0.1% (FML Liquifilm)
0.25% (FML Forte)
Dosage Forms & Strengths
ophthalmic suspension (in acetate form)
0.1% (Flarex)
ophthalmic suspension (in base form)
0.1% (FML Liquifilm)
0.25% (FML Forte)
ophthalmic (in ointment form)
0.1% (FML)
Refer to adult dosing
When fluorometholone is used together in combination with profenamine, this leads to reduction in therapeutic effectiveness of profenamine
When fluorometholone is aided by androstenediol, that promotes an increased risk of edema
Actions and Spectrum:
By inhibiting the immune system’s reaction, especially the generation of prostaglandins and other inflammatory mediators, fluorometholone works to reduce inflammation. This activity aids in easing eye symptoms like redness, edema, and itching.
fluorometholone’s range is constrained to the eye because it was created exclusively for ophthalmic usage. It is typically employed to treat inflammatory eye illnesses such uveitis and allergic conjunctivitis. It is not meant to be applied to other bodily parts.
Frequency not defined
Glaucoma
Hypercorticoidism (rare)
Cataract
Foreign body sensation
Eye pruritus
Lacrimation increased
Rash
Erythema of eyelid
Eyelid edema/eye swelling
Potentiate super infection
Visual disturbance (blurry vision)
Visual field defect
Slow wound healing
Allergic reactions
Eye discharge
Eye pain
Taste perversion
Post marketing reports
Cushing’s syndrome
Dysgeusia
Adrenal suppression
Contraindication/Caution:
Contraindication:
Caution:
Pregnancy warnings:
Pregnancy category: N/A
Lactation: Excreted into human milk is unknown
Pregnancy Categories:
Category A: Studies that were well-controlled and met expectations revealed no risk to the fetus in either the first or second trimester.
Category B: There were lack of studies on pregnant women and no evidence of risk to the foetus in animal experiments.
Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.
Category D: adequate data available with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.
Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women.
Category N: There is no data available for the drug under this category
Pharmacology
fluorometholone is absorbed by the cornea and reaches the anterior chamber of the eye when applied topically to the eye. It works by attaching to glucocorticoid receptors in target cells’ cytoplasm, which inhibits the transcription of several pro-inflammatory genes. As a result, less inflammatory mediators such prostaglandins, cytokines, and chemokines are produced, which in turn contributes to the signs of inflammation and edema in the eye.
Pharmacodynamics
fluorometholone interacts with glucocorticoid receptors on target cells in the eye to exert its pharmacodynamic effects. As fluorometholone reaches the target cell’s cytoplasm, it interacts to the glucocorticoid receptor to create a complex that then moves into the nucleus of the cell.
The complex interacts with certain DNA sequences known as glucocorticoid response elements (GREs) in the promoter regions of target genes in the nucleus. Anti-inflammatory genes are activated and some pro-inflammatory genes’ transcription is inhibited as a result of this interaction.
Pharmacokinetics
Absorption
Usually, fluorometholone is used topically to the eye. It enters the aqueous humor after being administered to the eye and is then absorbed via the cornea. fluorometholone’s absorption is affected by several variables, including the medication’s formulation, the health of the cornea, and the presence of other drugs.
Distribution
The anterior chamber of the eye has fluorometholone throughout, and this is where it works its pharmacological magic. fluorometholone has a very little systemic distribution because to its poor systemic absorption.
Metabolism
The liver is the primary site of metabolism for fluorometholone, where inactive metabolites are produced by hydrolysis and oxidation. fluorometholone’s metabolism may be impacted by several variables, including liver health and the presence of other drugs.
Elimination and excretion
The majority of fluorometholone’s metabolites are eliminated in the urine. fluorometholone and its metabolites are rapidly excreted from the eye, having a half-life of around 3 hours.
Administration
Usually, fluorometholone is used directly to the eye as eye drops or an ointment.
For eye drops,
Before handling the eye drops, give your hands a thorough wash.
Lean back and glance upward.
To create a little pocket, draw the lower eyelid down with your index finger.
To help the medication disperse evenly, let go of the lower eyelid and gently shut your eye for a short period of time.
Wait at least five minutes before using any more eye drops if you are using them.
For eye ointment,
Be sure to fully wash your hands before touching the ointment.
Lean back and glance upward.
To create a little pocket, draw the lower eyelid down with your index finger.
To help the ointment spread evenly, let go of the lower eyelid and briefly shut your eye.
Wait at least five minutes before applying any additional eye ointments if you want to use them.
Patient information leaflet
Generic Name: fluorometholone
Why do we use fluorometholone?
A corticosteroid drug called fluorometholone is mostly used to treat ocular irritation.
fluorometholone can aid in the relief of allergic conjunctivitis symptoms include eye redness, itching, and watering.
Inflammation in the middle layer of the eye can be treated with fluorometholone. It can aid in enhancing vision and easing discomfort brought on by this illness.
The cornea, the transparent front surface of the eye, can experience inflammation that can be treated with fluorometholone. It can aid in reducing the discomfort, redness, and light sensitivity linked to this illness
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