Inhibition of DNA synthesis: fluorouracil interferes with the production of DNA, which is essential for the growth and replication of cancer cells. By inhibiting DNA synthesis, fluorouracil can slow down or stop the growth of cancer cells.
Inhibition of RNA synthesis: fluorouracil also inhibits the production of RNA, which is another important component of the genetic material of cells. This interference with RNA synthesis can further inhibit the growth of cancer cells.
Induction of apoptosis: fluorouracil can induce programmed cell death, or apoptosis, in cancer cells. This helps to eliminate cancer cells from the body.
Spectrum:
Colorectal cancer: fluorouracil is commonly used in the treatment of colorectal cancer, either alone or in combination with other drugs.
Breast cancer: fluorouracil can be used to treat breast cancer, either as a standalone treatment or in combination with other drugs.
Skin cancer: fluorouracil is used to treat certain types of skin cancer, including basal cell carcinoma and squamous cell carcinoma.
Gastrointestinal cancer: fluorouracil can be used to treat other types of gastrointestinal cancer, such as pancreatic cancer and stomach cancer
