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Brand Name :
Prolixin, Modecate, Prolixin Decanoate, RhoFluphenazine, Prolixin Enanthate
Synonyms :
fluphenazine
Class :
Antipsychotics-Phenothiazine
Brand Name :
Prolixin, Modecate, Prolixin Decanoate, RhoFluphenazine, Prolixin Enanthate
Synonyms :
fluphenazine
Class :
Antipsychotics-Phenothiazine
Dosage Forms & Strengths
Tablet
1mg
2.5mg
5mg
10mg
Oral concentrate
5mg/mL
Solution
2.5mg/mL
25mg/mL
2.5-10 mg/day orally divided 3-4 times per day; may be increased up to 1-5 mg orally/IM
16.25-25 mg IM/SC every 2 weeks; once stable, the effects of a single injection may last 4-6 weeks
Safety and efficacy not established
It may enhance QTc interval when combined with perphenazine
the toxicity of either of the drugs is increased due to pharmacokinetic synergism
It may enhance sedation when combined with a shepherd's purse
It may diminish the effects when combined with chasteberry by pharmacodynamic antagonism
When encainide is used together with fluphenazine, this leads to a reduction in the encainide’s metabolism
When fluphenazine is used in combination with profenamine, this leads to reduction in therapeutic effectiveness of profenamine
sedative effects can be increased when fluphenazine is administered with papaverine
the toxicity of either of the drugs is increased due to pharmacokinetic synergism
When fluphenazine is used together in combination with profenamine, this leads to reduction in therapeutic effectiveness of profenamine
Adverse drug reactions
Frequency Not Defined
Akathisia
Dystonia
Dyskinesia
Confusion
Extrapyramidal symptoms
Muscle stiffness
Sedation
Weight gain
Erectile dysfunction
Parkinsonism
Anticholinergic effects
Pregnancy warnings:
AU TGA pregnancy category: C
US FDA pregnancy category: Not formally assigned.
Lactation:
Excreted into human milk is unknown
Pregnancy Categories:
Category A: well-controlled and Satisfactory studies show no risk to the fetus in the first or later trimester.
Category B: there was no evidence of risk to the fetus in animal studies, and there were no enough studies on pregnant women.
Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.
Category D: adequate data available with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.
Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women.
Category N: There is no data available for the drug under this category
Patient Information Leaflet
Generic Name: fluphenazine
Why do we use fluphenazine?
fluphenazine is a Phenothiazine antipsychotic. It is used to treat Psychotic Disorders.
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