furazolidone/metronidazole/dicyclomine

Action and Spectrum

Actions and spectrum: 

furazolidone, metronidazole and dicyclomine treat diarrhea. furazolidone and metronidazole are antibiotics that work by stopping the growth of bacteria and other microorganisms that cause diarrhea. dicyclomine is an anticholinergic medication that works by relaxing the muscles of the stomach and intestines (bowels). It stops sudden muscle contractions (spasms). In doing so, it reduces cramps, pain, bloating and discomfort. 

Drug Interaction

Adverse Reaction

Frequency not defined 

Dark colored urine 

Nervousness 

Dryness of mouth 

Nausea 

Headache 

Blurred vision 

Black Box Warning

Black Box Warning  

This may cause dizziness. 

Don’t drive or do anything that requires mental attention until you know how Furazolidone + Metronidazole + Dicyclomine affects you. 

Contraindication / Caution

Contraindication/Caution: 

Contraindication: 

Pregnancy / Lactation

Pregnancy consideration:  

US FDA pregnancy category: Not assigned 

Lactation:  

The excretion of this drug combination into breast milk is not known 

Pregnancy category:  

Category A: Studies that were well-controlled and met expectations revealed no risk to the foetus `in either the first or second trimester. 

Category B: There were a lack of studies on pregnant women and no evidence of risk to the foetus in animal experiments.   

Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.    

Category D: adequate data with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.   

Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women.    

Category N: There is no data available for the drug under this category

Pharmacology

Pharmacology: 

Antibiotics such as metronidazole and furazolidone prevent the growth of bacteria and other microorganisms that cause diarrhea. Dicyclomine is an anticholinergic agent that works by relaxing the muscles in the intestines and stomach, thereby avoiding sudden spasms or contractions. 

Pharmacodynamics: 

The combined effects of furazolidone, metronidazole, and dicyclomine on the body are referred to as the pharmacodynamics of the combination. Antibiotics with bactericidal features, such as metronidazole and furazolidone, prevent the growth of bacteria and other microorganisms. They accomplish this by interfering with a number of cellular functions, which finally stops bacterial growth. 

Contrarily, dicyclomine is an anticholinergic that works by causing the muscles in the intestines and stomach to relax. It does this by preventing the neurotransmitter acetylcholine, which is involved in muscle contractions, from acting. Dicyclomine therefore aids in the relief of gastrointestinal tract muscle spasms. 

Pharmacokinetics:  

Absorption  

Distribution  

Metabolism  

Elimination and excretion  

Half life: 

Adminstartion

Administration: 

Patient Information Leaflet

Patient information leaflet 

Generic Name: Furazolidone/Metronidazole/Dicyclomine  

Why do we use Furazolidone/Metronidazole/Dicyclomine? 

The combination of furazolidone, metronidazole and dicyclomine are used to treat diarrhea. This is also used against infections caused due to bacteria, amoebiasis, abdominal cramps etc.