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Brand Name :
Aldostix, Frusidip, Spiromide, Spirotic
Synonyms :
furosemide/spironolactone
Class :
Diuretics
Brand Name :
Aldostix, Frusidip, Spiromide, Spirotic
Synonyms :
furosemide/spironolactone
Class :
Diuretics
Dosage Forms & Strengths
Tablet
20 mg/50 mg
(furosemide/spironolactone)
Take daily 1 to 4 tablets orally
Not determined
Refer to adult dosing
Actions and Spectrum
furosemide is a loop diuretic. It works by inhibiting the reabsorption of sodium and chloride ions in the loop of Henle in the nephron of the kidney. This leads to increased excretion of water, sodium, chloride, potassium, and other electrolytes.
spironolactone is a potassium-sparing diuretic that primarily acts by blocking the effects of aldosterone, a hormone that regulates sodium and potassium balance in the body.
Frequency not defined
Fluid and electrolyte imbalance
Dizziness
Hypotension
Hepatic dysfunction
Glycosuria
Hirsutism
Nausea
Blurred vision
Headache
Hoarseness
Menstrual irregularities
Loss of libido
Impotence
Black Box Warning
None
Contraindication/Caution:
Contraindication:
Caution:
Pregnancy consideration:
Pregnancy category: N/A
Lactation: Excretion into human milk is unknown
Pregnancy Categories:
Category A: well-controlled and Satisfactory studies show no risk to the fetus in the first or later trimester.
Category B: there was no evidence of risk to the fetus in animal studies, and there were not enough studies on pregnant women.
Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.
Category D: adequate data with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.
Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women.
Category N: There is no data available for the drug under this category.
Pharmacology
furosemide is a loop diuretic that acts on the ascending loop of Henle in the nephron of the kidney.
It inhibits the reabsorption of sodium and chloride ions from the renal tubules, preventing their reabsorption into the bloodstream. pironolactone is a potassium-sparing diuretic, and it acts by blocking the effects of aldosterone.
It also promotes the excretion of sodium and water while conserving potassium.
Pharmacodynamics
furosemide’s primary pharmacodynamic effect is to increase the excretion of sodium and water, which leads to reduced fluid retention in the body.
spironolactone also has diuretic effects, but it differs from other diuretics because it conserves potassium. It can increase the excretion of sodium and water while sparing potassium.
Pharmacokinetics
Absorption
furosemide is having low onset of action. While spironolactone is absorbed after oral administration.
Distribution
furosemide/spironolactone both distributed throughout the extracellular fluid.
Metabolism
furosemide undergoes limited metabolism in the liver. While spironolactone is extensively metabolized in the liver.
Elimination and excretion
Both furosemide/spironolactone are excreted in urine.
Administration
furosemide/spironolactone is available in tablet form for oral administration.
Patient information leaflet
Generic Name: furosemide/spironolactone
Why do we use furosemide/spironolactone?
furosemide/spironolactone combination drug is frequently used to treat oedema.
furosemide/spironolactone may be used in the management of hypertension.
furosemide/spironolactone is also used for the treatment of Ascites due to congestive heart failure.
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