- June 7, 2022
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Brand Name :
Mylotarg
Synonyms :
gemtuzumab
Class :
Antineoplastics and Monoclonal Antibody
Dosage Forms & Strengths
Injection
4.5 mg per single-dose vial
Newly diagnosed CD33-positive acute myeloid leukemia (AML):
COMBINATION REGIMEN
Induction: 3 mg per m2 IV over 2hrs for Days 1, 4, and 7 given in combination with daunorubicin and cytarabine
the drug gemtuzumab during the second induction cycle gemtuzumab isn't encouraged for patients who require a second induction cycle
Consolidation: 3 mg per m2 IV over 2hrs on Day 1 in combination with daunorubicin and cytarabine
Newly diagnosed CD33-positive acute myeloid leukemia (AML):
SINGLE-AGENT REGIMEN:
Induction: 6 mg per m2 IV over 2hrs on Day 1 and 3 mg/m2 IV on Day 8
Continuation: 2 mg per m2 IV over 2hrs on Day 1 every four weeks
Relapsed or Refractory CD33-positive AML:
SINGLE-AGENT REGIMEN:
3 mg per m2 IV over 2hrs on Days 1, 4, and 7
a single course of gemtuzumab given for treatment in the relapsed or refractory setting
Dosage Forms & Strengths
Injection
4.5-mg per single-dose vial
Newly Diagnosed De Novo CD33-positive AML:
Combination Regimen:
age: >1year
BSA< 0.6 m2: 0.1 mg per kg IV over 2hrs
BSA>0.6 m2: 0.3 mg per m2 IV over 2hrs
INDUCTION 1:
gemtuzumab is given for Induction 1 once in combination with standard chemotherapy
In the second induction cycle, gemtuzumab isn't encouraged
INTENSIFICATION:
in the first or third intensification cycles, gemtuzumab isn't encouraged
gemtuzumab is given for Intensification 2 once in combination with standard chemotherapy
During Intensification 2, check for risks and potential benefits before giving gemtuzumab
Relapsed or Refractory CD33-positive AML:
SINGLE-AGENT REGIMEN:
age: > 2years
3 mg per m2 given IV over 2hrs on Days 1, 4, and 7
a single course of gemtuzumab for treatment in the relapsed or refractory setting
may diminish the therapeutic effect of vaccines
vaccinia immune globulin intravenous (Rx)
may diminish the therapeutic effect of vaccines
may diminish the therapeutic effect of vaccines
may diminish the therapeutic effect of vaccines
may diminish the therapeutic effect of vaccines
measles, mumps, rubella, and varicella vaccine, live (Rx)
may diminish the therapeutic effect of vaccines
measles mumps and rubella vaccine, live
may diminish the therapeutic effect of vaccines
measles, mumps, rubella and varicella vaccine, live
may decrease the therapeutic effects of vaccine
when both drugs are combined, there may be an increased QTC interval
when both drugs are combined, there may be an increased risk of adverse effects
when both drugs are combined, there may be an increased QTC interval
when both drugs are combined, there may be an increased risk of adverse effects
when both drugs are combined, there may be an increased risk of adverse effects
when both drugs are combined, there may be an increased QTC interval
when both drugs are combined, there may be an increased QTC interval
when both drugs are combined, there may be an increased QTC interval
when both drugs are combined, there may be an increased QTC interval
when both drugs are combined, there may be an increased QTC interval
when both drugs are combined, there may be an increased QTC interval
when both drugs are combined, there may be an increased QTC interval
when both drugs are combined, there may be an increased QTC interval
when both drugs are combined, there may be an increased QTC interval
when both drugs are combined, there may be an increased QTC interval
when both drugs are combined, there may be an increased QTC interval
when both drugs are combined, there may be an increased QTC interval
when both drugs are combined, there may be an increased QTC interval
when both drugs are combined, there may be an increased QTC interval
when both drugs are combined, there may be an increased QTC interval
may enhance the thrombogenic effect of immune globulin
may enhance the thrombogenic effect of immune globulin
poliovirus vaccine, live, trivalent
may diminish the therapeutic effect of vaccines
poliovirus vaccine inactivated
may diminish the therapeutic effect of vaccines
may diminish the therapeutic effect of vaccines
smallpox (vaccinia) vaccine, live
may diminish the therapeutic effect of vaccines
may diminish the therapeutic effect of vaccines
may diminish the therapeutic effect of vaccines
may diminish the therapeutic effect of vaccines
It may diminish the effects when combined with rozanolixizumab by receptor binding competition
measles, mumps, rubella, and varicella vaccine, live (Rx)
they decrease the efficacy of live vaccines
measles mumps and rubella vaccine, live
they decrease the efficacy of live vaccines
Adverse drug reactions:
Frequency defined
>10%
Hypophosphatemia
Hypokalemia
Infection
Hyponatremia
Prolonged thrombocytopenia
Hemorrhage
AST increased
Alkaline phosphatase increased
Fever
Infection
Increased AST
Bleeding
Nausea and vomiting
Constipation
Mucositis
Headache
Increased ALT
Rash
Sepsis
Pregnancy warnings:
Breastfeeding warnings:
Pregnancy Categories:
Patient Information Leaflet
Generic Name: Gemtuzumab (Rx)
Pronounced: gem-tuzum-ab
Why do we use Gemtuzumab?
Gemtuzumab is an antineoplastic drug used as single or in combination with other chemotherapy drugs to treat various types of acute myeloid leukemia.
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Founded in 2014, medtigo is committed to providing high-quality, friendly physicians, transparent pricing, and a focus on building relationships and a lifestyle brand for medical professionals nationwide.
MASSACHUSETTS – USA
60 Roberts Drive, Suite 313,
North Adams, MA 01247
MAHARASHTRA – INDIA
7, Shree Krishna, 2nd Floor,
Opp Kiosk Koffee,
Shirole Lane, Off FC Road,
Pune 411004, Maharashtra
