Actions and Spectrum:
Actions:
- Increases insulin secretion: glibenclamide binds to the sulfonylurea receptor on the beta cells of the pancreas, leading to the opening of ATP-sensitive potassium channels and subsequent cell membrane depolarization. It stimulates the release of insulin from the beta cells, which helps to lower blood glucose levels.
- Increases insulin sensitivity: glibenclamide can also increase the sensitivity of peripheral tissues to insulin, which can further help to lower blood glucose levels.
Spectrum:
glibenclamide has a broad spectrum of activity and is effective in managing blood glucose levels in individuals with type 2 diabetes mellitus. It is typically used with other medications, such as metformin, which has a different mechanism of action, to achieve better blood sugar control.
