RyR1 Structural Alterations Explain Statin-Associated Muscle Dysfunction
December 16, 2025
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Brand Name :
Preparation H, Recti Care
Synonyms :
glycerin/lidocaine
Class :
Antihemorrhoidal Agent, Local Anesthetic
Brand Name :
Preparation H, Recti Care
Synonyms :
glycerin/lidocaine
Class :
Antihemorrhoidal Agent, Local Anesthetic
Dosage Forms & Strengths
Cream
14.4%/5% (Glycerin/lidocaine)
Pad
20%/5% (Glycerin/lidocaine)
Apply topically to the affected area for around six times in a day especially at morning, evening, and after each bowel movement
Dosage Forms & Strengths
Cream
14.4%/5% (Glycerin/lidocaine)
Pad
20%/5% (Glycerin/lidocaine)
For ≥12 years old and Adolescents:
Apply topically to the affected area for around six times in a day especially at morning, evening, and after each bowel movement
Refer to adult dosing
Actions and Spectrum
glycerin is hygroscopic nature, and it attracts and retains moisture from the surrounding environment.
glycerin can act as a mild laxative to relieve constipation by drawing water into the intestines and promoting bowel movements.
lidocaine is a local anesthetic and antiarrhythmic drug used to numb specific areas of the body during medical procedures.
lidocaine works by blocking nerve signals in the area where it is applied, thereby reducing pain sensations.
Frequency not defined
None
Black Box Warning
None
Contraindication/Caution:
Contraindication:
Caution:
Pregnancy consideration:
Pregnancy category: N/A
Lactation: Excretion into human milk is unknown
Pregnancy Categories:
Category A: well-controlled and Satisfactory studies show no risk to the fetus in the first or later trimester.
Category B: there was no evidence of risk to the fetus in animal studies, and there were not enough studies on pregnant women.
Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.
Category D: adequate data with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.
Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women.
Category N: There is no data available for the drug under this category.
Pharmacology
glycerin can exert a mild laxative effect by drawing water into the intestines and promoting bowel movements.
lidocaine works by blocking nerve signals in the area where it is applied or injected, leading to temporary loss of sensation in that area.
Pharmacodynamics
Limited information available
Pharmacokinetics
Absorption
glycerin/lidocaine both well-absorbed through the skin when applied topically.
Distribution
glycerin/lidocaine both distributed throughout the body after absorption.
Metabolism
glycerin/lidocaine both metabolized in the liver through the liver’s enzymatic process.
Elimination and excretion
glycerin/lidocaine both eliminated in the urine.
Administration
glycerin is commonly applied topically in various forms such as moisturizing creams, lotions, and ointments.
While lidocaine is also used as a topically and is available in the form of creams, gels, sprays, and patches.
Patient information leaflet
Generic Name: glycerin/lidocaine
Why do we use glycerin/lidocaine?
It is used in skin conditions like soreness, burning, itching, and discomfort associated with hemorrhoids to give temporary relief from pain. They also provide temporarily relief from anorectal discomforts, and it protects irritated and inflamed perianal skin.
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