glymidine

medtigo

glymidine

Brand Name :

Gondafon

Synonyms :

glymidine

Class :

Oral hypoglycemics

Action and Spectrum

Actions and Spectrum:

glymidine, serves as a sulfonamide antidiabetic medication utilized for managing diabetes mellitus. Its action involves amplifying insulin secretion from the pancreas and augmenting tissue responsiveness to insulin.

Sharing structural similarities with sulfonylureas, researchers have examined its pharmacokinetics in both acute and chronic liver conditions. Categorized as an antidiabetic agent, it acts as an agonist for sulfonylurea receptors, pivotal in its effectiveness in diabetes management.

Dosing & Uses

Drug Interaction

Adverse Reaction

Frequency not defined

Hypoglycemia

Allergic reactions

Black Box Warning

Black Box Warning:

None

Contraindication / Caution

Contraindication/Caution:

Contraindication

Hypersensitivity to glymidine or related compounds.
Patients with heart blocks due to the potential interference with heart function.
Patients with a bleeding diathesis.
Patients with generalized rash, urticaria, or angioedema
Combining alcohol with Clonidine, which may cause dangerous sedative effects.
Certain medication interactions, such as barbiturate medications used for inducing sleep or treating seizures.

Caution

It is a sulfonamide antidiabetic drug, which means it may cause allergic reactions or side effects in some people who are sensitive to sulfonamides.
It may cause hypoglycemia (low blood sugar) if the dose is too high or the patient does not eat enough carbohydrates.
It may interact with other drugs, such as hydroxychloroquine, hydroxyprogesterone caproate, and iloperidone, and affect their therapeutic efficacy.

Pregnancy / Lactation

Pregnancy consideration:

US FDA pregnancy category: Not assigned

Lactation:  

Excreted into human milk: Not known.

Pregnancy category:

Category A: well-controlled and Satisfactory studies show no risk to the fetus in the first or later trimester.
Category B: there was no evidence of risk to the fetus in animal studies, and there were not enough studies on pregnant women.
Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.   
Category D: adequate data with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.   
Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women.   
Category N: There is no data available for the drug under this category.

Pharmacology

Pharmacology:

glymidine, is a sulfonamide antidiabetic drug used to treat diabetes mellitus. It functions by increasing insulin secretion from the pancreas and enhancing the sensitivity of tissues to insulin. Structurally related to sulfonylureas, its pharmacokinetics have been studied in acute and chronic liver diseases. This drug is classified as an antidiabetic agent and acts as a sulfonylurea receptor agonist, contributing to its efficacy in managing diabetes.

Pharmacodynamics:

Mechanism of action: glymidine is a sulfonamide antidiabetic drug related to sulfonylureas. Based on this class of drugs and general principles of antidiabetic mechanisms. glymidine is believed to exert its effects by:

Increasing insulin secretion from the pancreas helps lower blood glucose levels.
Enhancing the sensitivity of tissues to insulin, allowing cells to better respond to the insulin signal and uptake glucose from the bloodstream.

Pharmacokinetics:

Absorption

glymidine is likely absorbed from the gastrointestinal tract into the bloodstream, potentially through active transport mechanisms.

Distribution

Once in the bloodstream, glymidine would be distributed throughout the body to target tissues such as the pancreas.

Metabolism

glymidine may undergo hepatic metabolism, which could be enzymatically modified to inactive metabolites.

Elimination and Excretion

The drug and its metabolites are likely excreted primarily through the renal route and eliminated in urine. Some minor excretion through other pathways, like feces, might occur.

Adminstartion

Administration:

Oral administration

glymidine is administered orally. It is rapidly and completely absorbed following the oral administration. The drug has a high protein binding rate of around 90%. glymidine is a sulfonamide antidiabetic drug, structurally related to sulfonylureas, used to treat diabetes mellitus.

It was introduced as a possible alternative to other hypoglycemic agents. A healthcare professional should determine the recommended dosage and usage based on individual patient needs and medical history.

Patient Information Leaflet

Patient information leaflet

Generic Name: glymidine

Why do we use glymidine?

glymidine is a sulfonamide antidiabetic drug used to lower blood glucose by enhancing insulin secretion from the pancreas and enhancing the sensitivity of peripheral tissues to insulin.

glymidine

No data available for drug.

DRUG INTERACTION

glymidine

&

glymidine +

Contraindicated

Serious Use Alternative

Monitor Closely

Minor

glymidine

No data available for drug.

DRUG INTERACTION

glymidine

&

glymidine +

Contraindicated

Serious Use Alternative

Monitor Closely

Minor

medtigo

glymidine

Brand Name :

Synonyms :

Class :

Action and Spectrum

Dosing & Uses

Drug Interaction

Adverse Reaction

Black Box Warning

Contraindication / Caution

Pregnancy / Lactation

Pharmacology

Adminstartion

Patient Information Leaflet

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