Factors Influencing the Adoption of User-Administered Injectable Contraceptives in the United States
January 9, 2026
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Brand Name :
Lutrepulse
Synonyms :
gonadorelin acetate
Class :
Gonadotropin
Brand Name :
Lutrepulse
Synonyms :
gonadorelin acetate
Class :
Gonadotropin
Dosage Forms & Strengths
Solution
0.8 mg
In Females:
Administer initial dose of 5 mcg through intravenous or subcutaneous every 90 minutes via suitable pulsatile pump
Dose modification may be done every three weeks, if necessary
Treatment should be continued for 14 days after ovulation to maintain the corpus luteum
Not suggested
Refer to adult dosing
Actions and Spectrum
gonadorelin acetate acts on the pituitary gland, causing an initial release of luteinizing hormone (LH) and follicle-stimulating hormone (FSH).
These hormones stimulate the ovaries in females and the testes in males to produce sex hormones such as estrogen and progesterone in females, and testosterone in males.
Frequency not defined
Injection site irritation
Superficial thrombophlebitis
Post marketing reports
Inflammation at injection site
Ovarian hyperstimulation syndrome
Antibody development
Erythema at injection site
Abdominal pain
Anaphylactic shock, anaphylaxis
Fever and headache
Black Box Warning
None
Contraindication/Caution:
Contraindication:
Caution:
Pregnancy consideration:
Pregnancy category: N/A
Lactation: Excretion into human milk is unknown
Pregnancy Categories:
Category A: well-controlled and Satisfactory studies show no risk to the fetus in the first or later trimester.
Category B: there was no evidence of risk to the fetus in animal studies, and there were not enough studies on pregnant women.
Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.
Category D: adequate data with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.
Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women.
Category N: There is no data available for the drug under this category.
Pharmacology
gonadorelin acetate acts as a potent agonist of the GnRH receptor in the pituitary gland. It binds and activates these receptors, leading to a series of physiological responses.
Pharmacodynamics
In males, LH stimulates the production of testosterone by the Leydig cells in the testes. Testosterone, in combination with FSH, promotes spermatogenesis.
Pharmacokinetics
Absorption
gonadorelin acetate is absorbed into the bloodstream through the capillaries in the subcutaneous tissue.
Distribution
gonadorelin acetate is distributed throughout the body.
Metabolism
gonadorelin acetate undergoes metabolic processes in the body.
Elimination and excretion
gonadorelin acetate and its metabolites are eliminated through renal excretion.
Administration
gonadorelin acetate is commonly administered via subcutaneous (SC) or intravenous (IV) injection.
Patient information leaflet
Generic Name: gonadorelin acetate
Why do we use gonadorelin acetate?
gonadorelin acetate is commonly used in assisted reproductive technologies (ART) to induce controlled ovulation in women who have difficulty conceiving naturally.
gonadorelin acetate can be employed in cases of hypogonadism, a condition where the gonads (ovaries in females and testes in males) do not produce sufficient sex hormones.
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