gonadorelin acetate

Action and Spectrum

Actions and Spectrum 

gonadorelin acetate acts on the pituitary gland, causing an initial release of luteinizing hormone (LH) and follicle-stimulating hormone (FSH). 

These hormones stimulate the ovaries in females and the testes in males to produce sex hormones such as estrogen and progesterone in females, and testosterone in males. 

Drug Interaction

Adverse Reaction

Frequency not defined  

Injection site irritation 

Superficial thrombophlebitis 

Post marketing reports 

Inflammation at injection site  

Ovarian hyperstimulation syndrome 

Antibody development 

Erythema at injection site 

Abdominal pain 

Anaphylactic shock, anaphylaxis  

Fever and headache

Black Box Warning

Black Box Warning 

None

Contraindication / Caution

Contraindication/Caution: 

Contraindication: 

• The drug should not be used in individuals who have a known hypersensitivity or allergic reaction to gonadorelin acetate or any of its components. 
• gonadorelin acetate is contraindicated during pregnancy, as it can stimulate ovulation and may cause harm to the developing fetus. 

Caution: 

• Caution should be exercised in individuals with known or suspected disorders affecting the hypothalamic-pituitary-gonadal axis.  
• gonadorelin acetate may stimulate the growth of hormone-sensitive prostate cancer. Its use in such individuals should be carefully considered. 
• In males, the drug should not be used to treat testicular torsion. 

Pregnancy / Lactation

Pregnancy consideration: 

Pregnancy category: N/A 

Lactation: Excretion into human milk is unknown  

Pregnancy Categories:         

Category A: well-controlled and Satisfactory studies show no risk to the fetus in the first or later trimester. 

Category B: there was no evidence of risk to the fetus in animal studies, and there were not enough studies on pregnant women.  

Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women. 

Category D: adequate data with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits. 

Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women. 

Category N: There is no data available for the drug under this category. 

Pharmacology

Pharmacology  

gonadorelin acetate acts as a potent agonist of the GnRH receptor in the pituitary gland. It binds and activates these receptors, leading to a series of physiological responses. 

Pharmacodynamics 

In males, LH stimulates the production of testosterone by the Leydig cells in the testes. Testosterone, in combination with FSH, promotes spermatogenesis. 

Pharmacokinetics 

Absorption   

gonadorelin acetate is absorbed into the bloodstream through the capillaries in the subcutaneous tissue. 

Distribution 

gonadorelin acetate is distributed throughout the body. 

Metabolism 

gonadorelin acetate undergoes metabolic processes in the body. 

Elimination and excretion 

gonadorelin acetate and its metabolites are eliminated through renal excretion. 

Adminstartion

Administration 

gonadorelin acetate is commonly administered via subcutaneous (SC) or intravenous (IV) injection. 

Patient Information Leaflet

Patient information leaflet 

Generic Name: gonadorelin acetate 

Why do we use gonadorelin acetate? 

gonadorelin acetate is commonly used in assisted reproductive technologies (ART) to induce controlled ovulation in women who have difficulty conceiving naturally.   

gonadorelin acetate can be employed in cases of hypogonadism, a condition where the gonads (ovaries in females and testes in males) do not produce sufficient sex hormones.