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Brand Name :
PolyMast
Synonyms :
hetacillin
Class :
Dosage Forms & Strengths
Disposable syringe
10 ml
Fill each infected quarter with one syringe's full (10 mL) contents. Continue for a maximum of three treatments at 24-hour intervals
The causative organism should be looked into further if a noticeable improvement is not seen 2 days after treatment
Not determined
Refer to adult dosing
it may diminish the excretion rate when combined with zinc, resulting in an enhanced serum level
it may diminish the excretion rate when combined with zinc, resulting in an enhanced serum level
it may diminish the excretion rate when combined with zinc, resulting in an enhanced serum level
it may diminish the excretion rate when combined with zinc, resulting in an enhanced serum level
it may diminish the excretion rate when combined with zinc, resulting in an enhanced serum level
it may diminish the excretion rate when combined with xanthine derivates, resulting in an enhanced serum level
it may diminish the excretion rate when combined with xanthine derivates, resulting in an enhanced serum level
it may diminish the excretion rate when combined with xanthine derivates, resulting in an enhanced serum level
it may diminish the excretion rate when combined with antibiotics, resulting in an enhanced serum level
it may diminish the excretion rate when combined with vitamins, resulting in an enhanced serum level
it may diminish the excretion rate when combined with vitamins, resulting in an enhanced serum level
it may diminish the excretion rate when combined with vitamins, resulting in an enhanced serum level
it may diminish the excretion rate when combined with vitamins, resulting in an enhanced serum level
it may diminish the excretion rate when combined with vitamins, resulting in an enhanced serum level
it may diminish the excretion rate when combined with zinc compounds, resulting in an enhanced serum level
it may diminish the excretion rate when combined with zinc compounds, resulting in an enhanced serum level
it may diminish the excretion rate when combined with zinc compounds, resulting in an enhanced serum level
it may diminish the excretion rate when combined with zinc compounds, resulting in an enhanced serum level
it may diminish the excretion rate when combined with zinc compounds, resulting in an enhanced serum level
it may diminish the excretion rate when combined with antibiotics, resulting in an enhanced serum level
it may diminish the excretion rate when combined with antibiotics, resulting in an enhanced serum level
it may diminish the excretion rate when combined with antibiotics, resulting in an enhanced serum level
it may diminish the excretion rate when combined with vitamins, resulting in an enhanced serum level
it may diminish the excretion rate when combined with vitamins, resulting in an enhanced serum level
it may diminish the excretion rate when combined with vitamins, resulting in an enhanced serum level
it may diminish the excretion rate when combined with vitamins, resulting in an enhanced serum level
it may diminish the excretion rate when combined with vitamins, resulting in an enhanced serum level
Actions and Spectrum
A penicillin beta-lactam antibiotic called hetacillin is used to treat bacterial infections brought on by susceptible, typically gram-positive, organisms. Hetacillin is active against both anaerobic and aerobic gram-positive and gram-negative bacteria.
Frequency not defined
Uticaria
Angioedema
Haemolytic anaemia
Interstitial nephritis
Neutropaenia
Fever
Joint pains
Rashes
Thrombocytopaenia
Black Box Warning
None
Contraindication/Caution:
None
Pregnancy consideration:
Pregnancy category: N/A
Lactation: Excretion into human milk is unknown
Pregnancy Categories:
Category A: well-controlled and Satisfactory studies show no risk to the fetus in the first or later trimester.
Category B: there was no evidence of risk to the fetus in animal studies, and there were not enough studies on pregnant women.
Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.
Category D: adequate data with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.
Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women.
Category N: There is no data available for the drug under this category.
Pharmacology
Hetacillin is a semisynthetic penicillin prodrug that lacks antibacterial activity on its own but is transformed into ampicillin by the body.
The side chain amino group’s intramolecular attack on the lactam ring causes ampicillin to break down quickly.
Pharmacodynamics
Hetacillin prevents its own breakdown by enclosing the offending amino group. In susceptible bacteria, ampicillin binds to the penicillin binding proteins.
Autolytic enzymes found in bacterial cell walls, like autolysins, then mediate cell lysis.
Pharmacokinetics
Limited information available on ADME.
Administration
Fill each infected quarter with one syringe’s full contents. Continue for a maximum of three treatments at 24-hour intervals.
48 hours after treatment, if a clear improvement is not observed, more research on the causative organism needs to be done.
Use separate paper towels to dry the udder and teats after giving them a thorough wash in warm water with a dairy antiseptic of your choice.
Using a different swab for each teat, carefully scrub the orifice and teat end with 70% alcohol and permit to air dry.
Patient information leaflet
Generic Name: hetacillin
Why do we use hetacillin?
Hetacillin is indicated for the treatment of mastitis in lactating cows which is caused by susceptible strains of Escherichia coli, Staphylococcus aureus, Streptococcus dysgalactiae, and Streptococcus agalactiae.
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