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Brand Name :
hexamidina
Synonyms :
hexamidine
Class :
Eye Anti-Infectives & Antiseptics
Brand Name :
hexamidina
Synonyms :
hexamidine
Class :
Eye Anti-Infectives & Antiseptics
Actions and Spectrum:
Action:
Cell Membrane Disruption: hexamidine can disrupt the lipid bilayer of bacterial and fungal cell membranes. This disruption compromises the integrity of the cell membrane, leading to leakage of essential cellular components and eventual cell death.
Inhibition of Enzymes: hexamidine can inhibit the activity of certain enzymes in microorganisms, which are crucial for their survival and replication.
Spectrum:
Bacteria: hexamidine can be effective against both Gram-positive and Gram-negative bacteria. It is employed to manage bacterial infections affecting the skin and mucous membranes.
Fungi: hexamidine is effective against various fungi, including dermatophytes and yeasts. It treats fungal skin infections such as athlete’s foot and candidiasis.
Frequency not defined
allergic reactions
Transient ocular irritation
Black Box Warning:
None
Contraindication/Caution:
Hypersensitivity or Allergy: Individuals who have a known hypersensitivity or allergy to hexamidine or any of its ingredients should avoid using products containing hexamidine.
Open Wounds: hexamidine should not be applied to open wounds, cuts, or abrasions, as it may cause irritation and delay the healing process.
Mucous Membranes: Avoid applying hexamidine to mucous membranes, such as the eyes, mouth, or genital areas, as it may cause irritation and discomfort.
Pregnancy and Breastfeeding: While there is limited information regarding the safety of hexamidine during pregnancy and breastfeeding, it is generally recommended to consult with a healthcare professional before using hexamidine-containing products during these periods.
Children: hexamidine may not be recommended for use in infants and very young children without the guidance of a healthcare professional.
Pregnancy warnings:
Pregnancy category: N/A
Lactation: Excreted into human milk is unknown
Pregnancy Categories:
Category A: Studies that were well-controlled and met expectations revealed no risk to the fetus in either the first or second trimester.
Category B: There were a lack of studies on pregnant women and no evidence of risk to the fetus in animal experiments.
Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.
Category D: adequate data with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.
Category X: Drugs listed in this category outweigh the risks over benefits. Hence, these categories of drugs need to be avoided by pregnant women.
Category N: There is no data available for the drug under this category
Pharmacology: hexamidine is a topical antiseptic and antimicrobial agent used primarily in dermatology.
Pharmacodynamics:
Antiseptic Activity: hexamidine has broad-spectrum antimicrobial properties. It disrupts the cell membranes of bacteria and fungi, leading to their death.
Anti-Inflammatory: hexamidine exhibits gentle anti-inflammatory characteristics, which can aid in diminishing redness and swelling linked to skin infections or irritations.
Pharmacokinetics:
Absorption
When applied topically, hexamidine is primarily absorbed through the skin. The extent of absorption can vary but is generally limited because it is intended for external use only.
Distribution
After absorption, hexamidine may distribute locally within the skin and superficial tissues. It is not known to have significant systemic distribution.
Metabolism
hexamidine is not significantly metabolized in the body.
Excretion and Elimination
The medication’s primary mode of elimination involves its unaltered excretion through the urinary system.
Administration:
Topical Use: hexamidine is primarily administered topically.
Patient information leaflet
Generic Name: hexamidine
Why do we use hexamidine?
Topical Antiseptic: hexamidine is often included in topical antiseptic solutions, creams, and ointments. It helps to disinfect and clean wounds, burns, and minor skin injuries, reducing the risk of infection.
Treatment of Skin Conditions: hexamidine-containing products manage various skin conditions. It can help reduce inflammation and control the growth of microorganisms on the skin.
Hair Care: Some shampoos and hair care products contain hexamidine to combat dandruff and other scalp conditions caused by fungi or bacteria.
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