hyaluronan 

Action and Spectrum

Actions and Spectrum: 

hyaluronan supplements have no effects because the FDA does not regulate them for medical use. 

hyaluronan supplements are often considered safe for most people when prescribed in terms of its range.

Drug Interaction

Adverse Reaction

Black Box Warning

Contraindication / Caution

Contraindication: 

• hyaluronan hypersensitivity or allergy 
• Anaphylaxis or severe allergic responses in the past

Caution: 

• hyaluronan supplements are advised against use during pregnancy and nursing since there is little knowledge on their safety. 
• Supplements containing hyaluronan may make bleeding more likely in patients with bleeding problems or those using anticoagulant or antiplatelet drugs. 
• Supplements containing hyaluronan should be taken with caution in this population since there is some worry that they can encourage tumor growth in patients with specific forms of cancer. 
• hyaluronan supplements should be stopped at least two weeks before to the scheduled operation since they may increase the risk of bleeding. 

Pregnancy / Lactation

Pregnancy warnings:     

Pregnancy category: N/A 

Lactation: N/A 

Pregnancy Categories:         

Category A: Studies that were well-controlled and met expectations revealed no risk to the fetus in either the first or second trimester. 

Category B: There were lack of studies on pregnant women and no evidence of risk to the foetus in animal experiments.   

Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.    

Category D: adequate data available with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.   

Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women.    

Category N: There is no data available for the drug under this category

Pharmacology

Pharmacology 

hyaluronan is a substance found in the body that aids in tissue regeneration and wound healing as well as lubricating and cushioning joints. Another vital component of the skin is hyaluronan, which keeps the skin moisturized and supple. 

Pharmacodynamics 

hyaluronan functions as a lubricant and shock absorber in the joints, cushioning and defending the joint surfaces. hyaluronan helps in the hydration and suppleness of the skin and may also speed up the recovery of wounds. 

Pharmacokinetics 

Absorption   

Because of their large molecular weight, oral hyaluronan supplements are assumed to be poorly absorbed by the body. According to some research, just a tiny portion of hyaluronan taken orally is absorbed into the circulation; the remainder of the supplement may be eliminated in the feces unaltered. 

Distribution 

The body naturally produces hyaluronan, which is present in numerous tissues, including the skin and joints. hyaluronan may spread throughout the body and build up in various tissues when given as a supplement. 

Metabolism 

hyaluronan is assumed to be broken down by enzymes and eliminated in the urine or feces rather than being metabolized by the body. According to certain research, hyaluronan may be removed from the body after a few hours of treatment because of its short half-life in the body. 

Elimination and excretion 

The majority of hyaluronan is eliminated in urine and feces unaltered. According to certain research, taking oral hyaluronan supplements may cause more of the substance to be excreted in the urine. 

Adminstartion

Administration:  

There are several different kinds of hyaluronan supplements, including liquids, pills, and capsules. Although they may also be administered topically to the skin, they are commonly taken orally. 

Patient Information Leaflet

Patient information leaflet 

Generic Name: hyaluronan 

Why do we use hyaluronan? 

The natural substance hyaluronan, which is found in joint fluid, is supposed to lubricate and cushion the joints. hyaluronan supplements may assist to increase joint mobility, lessen joint discomfort, and reduce stiffness, according to certain research. 

In the skin, hyaluronan is a naturally occurring component that supports moisture and suppleness. hyaluronan supplements may assist to enhance skin moisture and lessen the visibility of wrinkles and fine lines, according to certain research. 

By encouraging cell migration and proliferation and by controlling inflammation, hyaluronan may aid in the healing of wounds. hyaluronan supplements may aid to promote wound healing, according to certain research.