Evaluating Match Rates Between OASIS Assessments and Medicare Claims Data
April 4, 2026
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Brand Name :
Vytone, Alcortin, Dermazene
Synonyms :
hydrocortisone/iodoquinol
Class :
Topical Corticosteroids, anti-infectives
Brand Name :
Vytone, Alcortin, Dermazene
Synonyms :
hydrocortisone/iodoquinol
Class :
Topical Corticosteroids, anti-infectives
Dosage forms & Strengths
Cream
1% hydrocortisone /1% iodoquinol
2% hydrocortisone /1% iodoquinol
Dosage forms & Strengths
Cream
1% hydrocortisone /1% iodoquinol
2% hydrocortisone /1% iodoquinol
Refer to adult dosing.
Actions and Spectrum:
hydrocortisone and iodoquinol are two different medications with different actions and spectrums. hydrocortisone is a steroid medication that has anti-inflammatory and immunosuppressive effects.
It works by inhibiting the production of inflammatory molecules such as prostaglandins and leukotrienes, which are involved in the body’s inflammatory response. hydrocortisone is commonly used to treat skin conditions such as eczema, psoriasis, and dermatitis, as well as inflammatory conditions such as arthritis.
iodoquinol is an antiprotozoal medication that is used to treat infections caused by various types of parasites, such as Entamoeba histolytica and Giardia lamblia. It works by interfering with the metabolism of these parasites, leading to their death. iodoquinol is effective against a broad spectrum of parasites but is not effective against all types of parasites.
Frequency not defined
iodoquinol
Vertigo
Optic neuritis
Fever
Skin eruptions
Chills
Thyroid gland enlargement
Peripheral neuropathy
Urticaria
Diarrhea
Optic atrophy
Anal itching
Nausea/vomiting
Chills
Rash
Headache
hydrocortisone
Pruritus
Leukoderma
Acneform lesions
Urticaria
Allergic contact dermatitis
Hypertrichosis
Intracranial hypertension
Skin atrophy
Pigmentation changes
Pustulation
Perioral dermatitis
Striae
Pigmentation changes
HPA suppression
Black Box Warning:
The combination medication of hydrocortisone and iodoquinol does not have a black box warning, but both medications individually have their own warnings.
hydrocortisone has a black box warning regarding the possibility of serious and potentially life-threatening side effects with long-term use. Prolonged use of corticosteroids such as hydrocortisone can lead to adrenal suppression, which can result in diminished production of cortisol by the adrenal glands.
This can cause a various type of symptoms, including fatigue, weight loss, weakness, low blood pressure, and electrolyte imbalances. hydrocortisone should be used cautiously and under the supervision of a healthcare professional. iodoquinol does not have a black box warning.
Contraindication/Caution:
Contraindication
The combination medication of hydrocortisone and iodoquinol is contraindicated in patients who have a history of hypersensitivity to any of its components or to other iodine-containing compounds.
Individually, hydrocortisone is contraindicated in patients with systemic fungal infections, untreated bacterial infections, viral infections such as herpes simplex or chickenpox, and tuberculosis. It should also be used with caution in patients with liver disease, diabetes, or a history of peptic ulcers.
iodoquinol is contraindicated in patients with a history of optic neuritis or other visual disturbances related to iodoquinol use, as well as in patients with a history of iodine hypersensitivity. It should also be used with caution in patients with liver disease, as it may increase the risk of liver damage.
Caution
There are several cautions that should be taken into consideration when using the combination medication of hydrocortisone and iodoquinol.
First, the use of this combination medication should be avoided during pregnancy condition and lactation unless the potential benefits outweigh the risks. hydrocortisone can cross the placenta and may cause fetal harm, while iodoquinol can be excreted in breast milk.
Second, patients with liver disease should use hydrocortisone and iodoquinol with caution, as both medications can cause liver damage. Regular liver function tests may be recommended to monitor for any potential liver problems.
Third, patients who are taking other medications should inform their healthcare provider before using hydrocortisone and iodoquinol, as these medications may interact with other drugs. For example, hydrocortisone can interact with blood thinners, antidiabetic medications, and certain vaccines.
Fourth, long-term use of hydrocortisone can lead to adrenal suppression, which can cause fatigue, weakness, and other symptoms. Patients who are taking hydrocortisone for an extended period of time should be monitored for signs of adrenal suppression.
Finally, patients should be aware that iodoquinol may cause skin discoloration, particularly in areas that are exposed to sunlight. Patients should avoid prolonged exposure to sunlight and wear protective clothing and sunscreen when outdoors.
As always, it is important to discuss any concerns or questions with your healthcare provider before using hydrocortisone and iodoquinol.
Pregnancy consideration:
US FDA pregnancy category: C
Lactation:
Excreted into human milk is Not known.
Pregnancy category:
Pharmacology:
hydrocortisone is a corticosteroid that works by binding to glucocorticoid receptors in the cells, leading to the inhibition of inflammatory responses. It also inhibits the activity of phospholipase A2, which is responsible for the synthesis of various inflammatory mediators such as prostaglandins and leukotrienes. hydrocortisone also reduces migration of the inflammatory cells, such as macrophages and neutrophils, to the site of inflammation, leading to a reduction in redness, swelling, and itching.
iodoquinol, on the other hand, is an iodine-containing compound that has antibacterial, antifungal, and antiprotozoal properties. It works by interfering with various metabolic processes in the microorganisms, leading to their death. iodoquinol disrupts the DNA synthesis, RNA synthesis, and protein synthesis of the microorganisms, inhibiting their growth and reproduction.
The combination of hydrocortisone and iodoquinol in a single medication provides a synergistic effect in treating certain skin conditions. hydrocortisone reduces inflammation and itching, while iodoquinol inhibits the growth of microorganisms that can cause skin infections. Together, they can help to reduce the symptoms of the skin condition and promote healing of the affected area.
Pharmacodynamics:
The pharmacodynamics of hydrocortisone/iodoquinol combination medication is related to the individual pharmacodynamics of each component.
hydrocortisone is a corticosteroid that acts by binding to glucocorticoid receptors in the cells, leading to the inhibition of inflammatory responses. hydrocortisone reduces the production of various inflammatory mediators such as prostaglandins and leukotrienes, and also inhibits migration of the inflammatory cells to the site of inflammation. As a result, hydrocortisone reduces inflammation, swelling, and itching associated with various skin conditions.
iodoquinol is an iodine-containing compound that has antibacterial, antifungal, and antiprotozoal properties. iodoquinol works by inhibiting the synthesis of DNA, RNA, and proteins in microorganisms, leading to their death. iodoquinol has activity against various microorganisms such as bacteria, fungi, and protozoa, which can cause or worsen certain skin conditions.
Pharmacokinetics:
The pharmacokinetics of hydrocortisone/iodoquinol combination medication can vary depending on the formulation and mode of administration. When applied topically, the medication is primarily absorbed through the skin.
hydrocortisone is rapidly absorbed through the skin and enters the systemic circulation, where it is metabolized in liver and excreted in the urine. The absorption of hydrocortisone can be affected by various factors such as the thickness and hydration of the skin, the area of application, and the presence of other medications.
iodoquinol is also absorbed through the skin and enters the systemic circulation. It is metabolized in liver and excreted in the urine and feces. The absorption of iodoquinol can also be affected by various factors such as the thickness and hydration of the skin, the area of application, and the presence of other medications.
Administration:
Topical administration
hydrocortisone/iodoquinol combination medication is available as a topical cream or ointment, which should be applied near the affected area of the skin as directed by a healthcare provider.
Before applying the medication, the affected area should be cleaned and dried thoroughly. A thin layer of the medication should be applied to the affected area and gently rubbed in until it is absorbed. The medication should be applied according to the prescribed schedule and should not be used for longer than recommended.
It is important to avoid getting the medication in the eyes, mouth, or nose, as it may cause irritation. If accidental contact occurs, the affected area should be rinsed thoroughly with water.
Patients should not cover the treated area with a bandage or other covering unless directed to do so by a healthcare provider. Doing so may increase the absorption of the medication and increase the possibility of side effects.
Patients should also be aware that hydrocortisone and iodoquinol are not intended for use in the eyes or on mucous membranes, and should not be ingested.
As with any medication, it is key to follow the instructions provided by your healthcare provider and to report any side effects or concerns promptly.
Patient information leaflet
Generic Name: hydrocortisone/iodoquinol
Pronounced: [ eye-oh-doe-KWIN-ole-& hye-droe-KOR-ti-sone ]
Why do we use hydrocortisone/iodoquinol?
hydrocortisone/iodoquinol combination medication is used to treat certain skin conditions, including eczema, psoriasis, and other inflammatory skin disorders. The medication works by reducing inflammation and itching and by inhibiting the growth of certain microorganisms.
hydrocortisone is a corticosteroid that works by reducing inflammation and itching. It is also a mild vasoconstrictor, which helps to reduce redness and swelling in the affected area.
iodoquinol is an iodine-containing compound that has antibacterial, antifungal, and antiprotozoal properties. It acts by inhibiting the growth and reproduction of certain microorganisms that can cause skin infections.
Together, hydrocortisone and iodoquinol provide a synergistic effect in the treatment of certain skin conditions. The medication can help to reduce inflammation and itching, control the growth of microorganisms, and promote healing of the affected area.
It is important to note that hydrocortisone/iodoquinol combination medication should only be used for the conditions prescribed by a healthcare provider and should not be used for other skin conditions or without medical supervision.
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