hydrocortisone probutate topical

Action and Spectrum

Actions and spectrum: 

hydrocortisone probutate is a synthetic corticosteroid with anti-inflammatory, antipruritic, and vasoconstrictive properties. It works by binding to glucocorticoid receptors and inhibiting the release of inflammatory mediators such as prostaglandins and leukotrienes, resulting in a decrease in inflammation and itching. 

hydrocortisone probutate is used topically to treat inflammatory skin conditions such as eczema, dermatitis, psoriasis, and other allergic reactions. It is effective in reducing itching, redness, and swelling of the affected skin areas. 

Drug Interaction

Adverse Reaction

Frequency defined 

<1% 

Paresthesia  

1-10% 

Stinging (1%) 

Burning (2%)  

Frequency not defined 

Irritation 

Folliculitis 

Acneiform eruptions 

Perioral dermatitis 

Secondary infections 

Striae 

Itching 

Dryness 

Hypertrichosis 

Hypopigmentation 

Allergic contact dermatitis 

Skin atrophy 

Miliaria  

Post marketing Reports 

Papulovesicular rash 

Erythema 

Rash 

Dryness 

Pruritus 

Black Box Warning

Contraindication / Caution

Contraindication/Caution: 

Contraindication: 

hydrocortisone probutate topical is contraindicated in patients with a history of hypersensitivity to the formulation. It is also contraindicated in patients with viral, fungal, or bacterial skin infections, tuberculosis or syphilitic skin infections, perioral dermatitis, acne vulgaris, rosacea, or other skin conditions, and in patients with skin atrophy or striae.  

Caution: 

• Use in pregnancy and lactation: hydrocortisone probutate topical should only be used in pregnancy and lactation if the potential benefits outweigh the risks.  
• Use in children: hydrocortisone probutate topical should be used with caution in children, as they may absorb the medication more readily through the skin than adults.  
• Use in certain skin conditions: hydrocortisone probutate topical should be used under caution in patients with certain skin conditions such as rosacea, acne, or perioral dermatitis as it may exacerbate the condition. 
• Use in infections: hydrocortisone probutate topical should not be used in areas of the skin affected by infections, as it can make the infection worse. 
• Use with other medications: hydrocortisone probutate topical may interact with other medications, especially other steroid medications, and caution should be taken when using it with other medications. 

Comorbidities: 

• Diabetes mellitus: Corticosteroids may increase blood glucose levels and worsen glycemic control in patients with diabetes mellitus. 
• Hypertension: Corticosteroids can cause sodium and water retention, which may worsen hypertension. 
• Osteoporosis: Prolonged use of corticosteroids may increase the risk of osteoporosis, particularly in postmenopausal women. 
• Cushing’s syndrome: Prolonged use of high-dose corticosteroids can cause Cushing’s syndrome, a condition characterized by central obesity, facial rounding, and thinning of the skin. 
• Infections: Topical corticosteroids can suppress the immune system and increase the risk of infections, particularly fungal infections. 
• Skin atrophy: Prolonged use of topical corticosteroids can cause skin atrophy, particularly in areas with thin skin such as the face, groin, and axillae. 
• Pregnancy and lactation: The safety of hydrocortisone probutate topical during pregnancy and lactation has not been established, and its use in these populations should be weighed against potential risks and benefits. 

Pregnancy / Lactation

Pregnancy consideration: US FDA pregnancy category: C 

Lactation: It is not known whether hydrocortisone probutate topical is excreted in breast milk.  

Pregnancy category: 

• Category A: Satisfactory and well-controlled studies show no risk to the fetus in the first or later trimester. 
• Category B: There is no evidence of risk to the fetus found in animal reproduction studies and there are not enough studies on pregnant women. 
• Category C: Adverse effects on the fetus found with evidence in animal reproduction studies and no adequate evidence for an effect in humans, care must be taken for potential risks in pregnant women. 
• Category D: There is adequate data available with sufficient evidence of human fetal risk from various platforms, but despite potential risks may be used only in emergency cases for potential benefits. 
• Category X: Drugs listed in this category outweigh risks over benefits These category drugs should be prohibited for pregnant women. 
• Category N: There is no data available for the drug under this category. 

Pharmacology

Pharmacology: 

hydrocortisone probutate is a synthetic glucocorticoid with anti-inflammatory and immunosuppressive properties. It works by binding to the glucocorticoid receptor and inhibiting the expression of pro-inflammatory genes. It also suppresses the migration of polymorphonuclear leukocytes and reduces capillary permeability. 

As a topical medication, hydrocortisone probutate is rapidly absorbed into the skin and enters systemic circulation. However, the amount of drug that reaches systemic circulation is minimal due to its low systemic bioavailability. The drug has a short half-life and is rapidly metabolized in the liver to inactive metabolites, which are excreted in the urine.  

Pharmacodynamics: 

hydrocortisone probutate is a synthetic glucocorticoid used in topical preparations for its anti-inflammatory and immunosuppressive effects. It exerts its pharmacodynamic effects by binding to cytoplasmic glucocorticoid receptors in target cells, leading to the modulation of gene transcription and a reduction in the synthesis and release of inflammatory mediators such as cytokines, chemokines, and prostaglandins.

The reduction in inflammation results in a decrease in erythema, edema, and pruritus, which are the clinical symptoms of inflammation. Additionally, hydrocortisone probutate inhibits the migration of leukocytes to the site of inflammation, leading to a reduction in the infiltration of immune cells into the affected tissues.  

Pharmacokinetics: 

Absorption 

hydrocortisone probutate is minimally absorbed through the skin, with only a small fraction entering the systemic circulation. 

Distribution 

Once absorbed, hydrocortisone probutate is distributed to the local tissues and acts primarily at the site of application. 

Metabolism 

hydrocortisone probutate is metabolized in the liver and excreted in the urine as metabolites. 

Elimination and excretion 

The elimination half-life of hydrocortisone probutate is less than 3 hours. Most of the drug and its metabolites are excreted in the urine within 24 hours of application. 

Adminstartion

Administration: 

hydrocortisone probutate is a topical medication that is applied directly to the skin. It is available as a cream, lotion, or ointment. The medication should be applied thinly and evenly to the affected area and should be rubbed gently until it is absorbed. It is usually applied 1-3 times per day or as directed by a healthcare provider. 

It is important to clean and dry the affected area before applying hydrocortisone probutate, and to avoid getting the medication in the eyes or mouth. It should not be applied to open wounds or broken skin. 

Patient Information Leaflet

Patient information leaflet 

Generic Name: hydrocortisone probutate topical 

Pronounced: [ hye-droe-KOR-ti-sone]  

Why do we use hydrocortisone probutate topical? 

hydrocortisone probutate topical is a medication used to treat skin inflammation, itching, and redness caused by a variety of conditions, such as eczema, dermatitis, and psoriasis.

It is a topical corticosteroid that works by reducing inflammation and suppressing the immune system in the affected area. hydrocortisone probutate is only used on the skin and is not recommended for use in the eyes, mouth, or genital areas.