Effectiveness of Tai Chi vs Cognitive Behavioural Therapy for Insomnia in Middle-Aged and Older Adults
November 27, 2025
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Brand Name :
Advil Allergy Sinus, Advil Multi-Symptom Cold
Synonyms :
ibuprofen/chlorpheniramine/pseudoephedrine
Class :
Decongestant, Antihistamine, Analgesic Combos
Brand Name :
Advil Allergy Sinus, Advil Multi-Symptom Cold
Synonyms :
ibuprofen/chlorpheniramine/pseudoephedrine
Class :
Decongestant, Antihistamine, Analgesic Combos
Dosage forms & Strengths
Caplet
200 mg ibuprofen/2 mg chlorpheniramine/30 mg pseudoephedrine
Allergy Symptoms And Common Cold
Take one tablet orally every 4 to 6 hours as required
Do not take more than 6 tablets in one day
Dosage forms & Strengths
Caplet
200 mg ibuprofen/2 mg chlorpheniramine/30 mg pseudoephedrine
Allergy Symptoms And Common Cold
For <12 years old: Safety and efficacy not established
For 12 years or older:
Take one tablet orally every 4 to 6 hours as required
Do not take more than 6 tablets in one day
Refer to adult dosing.
Actions and Spectrum:
ibuprofen, a nonsteroidal anti-inflammatory drug that is commonly used for its analgesic (pain-relieving), antipyretic (fever-reducing), and anti-inflammatory properties. It acts by inhibiting the production of prostaglandins, which are substances in the body that cause inflammation, pain, and fever. ibuprofen is used to relieve mild-to-moderate pain associated with conditions such as headaches, menstrual cramps, dental pain, and arthritis.
chlorpheniramine is an antihistamine that is used to treat symptoms of allergies, such as runny nose, sneezing, and itching. It acts by blocking the effects of histamine, which is a substance released by the body in response to an allergic reaction. chlorpheniramine can also cause drowsiness, which is why it is often included in over-the-counter sleep aids.
pseudoephedrine, a decongestant that is used to relieve nasal congestion associated with allergies, colds, and flu. It acts by constricting blood vessels in the nasal passages, which reduces swelling and congestion. pseudoephedrine can also increase blood pressure and heart rate, which is why it is sometimes regulated and sold behind the pharmacy counter.
Frequency not defined
Insomnia
Gastrointestinal upset
Drowsiness
Xerostomia
Urinary retention
Contraindication/Caution:
Contraindication
The combination of ibuprofen, chlorpheniramine, and pseudoephedrine may have contraindications, which are situations or conditions in which the medication should not be used. Some potential contraindications for this combination include:
Caution
The combination of ibuprofen, chlorpheniramine, and pseudoephedrine may have cautions, which are situations or conditions in which the medication should be used with caution or careful monitoring. Some potential cautions for this combination include:
Pregnancy consideration:
US FDA pregnancy category: Not assigned.
Lactation:
Excreted into human milk is Not known.
Pregnancy category:
Pharmacology:
ibuprofen, chlorpheniramine, and pseudoephedrine are all active ingredients in the combination medication, and each has its own pharmacological properties.
ibuprofen, a nonsteroidal anti-inflammatory drug (NSAID) that acts by inhibiting the production of prostaglandins(PG), which are substances in the body that cause inflammation, pain, and fever. By reducing the production of prostaglandins, ibuprofen helps to relieve pain and reduce fever.
chlorpheniramine is a first-generation antihistamine that works by blocking the action of histamine, a chemical in the body that causes allergy symptoms such as sneezing, runny nose, and watery eyes. By blocking histamine, chlorpheniramine helps to alleviate these symptoms.
pseudoephedrine is a sympathomimetic drug that works by stimulating the sympathetic nervous system, which is responsible for the body’s “fight or flight” response. This stimulation causes constriction of blood vessels in the nasal passages, which helps to reduce nasal congestion and sinus pressure.
Pharmacodynamics:
The pharmacodynamics of ibuprofen, chlorpheniramine, and pseudoephedrine in combination are complex, as each drug has different mechanisms of action that can interact with one another.
ibuprofen’s mechanism of action involves inhibiting the production of prostaglandins, which can lead to decreased pain and fever. chlorpheniramine’s mechanism of action involves blocking the action of histamine, which can lead to decreased allergy symptoms such as sneezing, runny nose, and watery eyes. pseudoephedrine’s mechanism of action involves stimulating the sympathetic nervous system, leading to constriction of blood vessels in the nasal passages and decreased nasal congestion and sinus pressure.
When these drugs are combined, they can have additive or even synergistic effects on these mechanisms of action.
Pharmacokinetics:
The pharmacokinetics of ibuprofen and pseudoephedrine can vary depending on the formulation of the medication and individual patient factors.
ibuprofen is rapidly absorbed after oral administration, with peak plasma concentrations occurring within 1-2 hours. It is extensively bound to plasma proteins and is metabolized in liver by oxidation and conjugation. The metabolites are eliminated in the urine and feces. The half-life of ibuprofen is approximately 2-4 hours in adults, and it can be longer in individuals with impaired liver or kidney function.
pseudoephedrine is also rapidly absorbed after oral administration, with peak plasma concentrations occurring within 1-2 hours. It is extensively metabolized in the liver by oxidation and conjugation, and the metabolites are excreted in the urine. The half-life of pseudoephedrine is approximately 4-6 hours in adults, but it may be longer in individuals with impaired liver or kidney function.
It is key to note that the pharmacokinetics of ibuprofen and pseudoephedrine may be affected by factors such as age, gender, body weight, liver or kidney function, and the presence of other medications. It is also main important to follow the dosage instructions provided by a healthcare provider or as indicated on the medication label to ensure safe and effective use of the medication.
Administration:
Oral administration
The combination of ibuprofen, chlorpheniramine, and pseudoephedrine is usually administered orally in the form of tablets or capsules. The recommended dosage and administration instructions may vary depending on the specific product and the patient’s age, medical history, and other factors.
It is key to follow the dosage instructions provided by the healthcare provider or as indicated on the medication label, and not to exceed the recommended dose or duration of treatment. The medication may be taken with or without food, but taking it with food may help to reduce gastrointestinal side effects.
It is also important to avoid taking other medications that contain ibuprofen, chlorpheniramine, or pseudoephedrine while taking this combination, as this may result in an overdose or unwanted side effects.
If a dose is missed, it is recommended to take it as soon as possible. However, if the next scheduled dose is missed, it should be skipped and the following dose should be taken at the appropriate time. It is important to avoid taking a double dose of the medication to compensate for the missed dose.
As with any other medication, it is important to talk to a physician or pharmacist before taking this combination, to ensure that it is safe and appropriate for you based on your medical history, current medications, and other factors.
Patient information leaflet
Generic Name: ibuprofen/chlorpheniramine/pseudoephedrine
Pronounced: [ KLOR-fen-EER-a-meen, EYE-bue-pro-fen, SOO-doe-ee-FED-rin ]
Why do we use ibuprofen/chlorpheniramine/pseudoephedrine?
ibuprofen, chlorpheniramine, and pseudoephedrine are combined in some over-the-counter medications to provide relief from symptoms associated with colds, allergies, and other respiratory conditions. The combination medication may be used to alleviate:
ibuprofen, an NSAID, helps to relieve pain and reduce fever, while chlorpheniramine is an antihistamine that helps to alleviate allergy symptoms such as sneezing, runny nose, and watery eyes. pseudoephedrine is generally used as decongestant that helps to relieve nasal congestion and sinus pressure.
It is important to note that this combination medication should not be used to treat chronic conditions or long-term symptoms, and it should not be used in children below the age of 12 without a healthcare provider’s recommendation. It is also important to read the label and follow the recommended dosage and administration instructions, and to talk to a healthcare provider or pharmacist before taking this combination if you have any questions or concerns.
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