Anthropometric Measurements as Predictors of Low Birth Weight Among Tanzanian Neonates: A Hospital-Based Study
November 7, 2025
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Brand Name :
primaxin
Synonyms :
imipenem/cilastatin
Class :
Dosage Forms & StrengthsÂ
Powder for injectionÂ
250mg/250mgÂ
500mg/500mgÂ
Skin, Gynaecology, And Upper Respiratory Tract InfectionsÂ
Mild to moderate:
500 - 700
mg
Solution
Injection
every 12 hours
500
mg
Solution
Intravenous (IV)
every 6 hours
Mild to moderate:
250 - 500
mg
Solution
Injection
every 6 hours
Severe: 500mg Intravenous every 6 hours or 1g every 8 hours for 4-7 days
Uncomplicted:250mg intravenous every 6 hours
Complicated:500mg intravenous every 6 hours
Dose Adjustments
Renal impairment
CrCl<5 ml/min/1.73m2: Only use IV if hemodialysis will start within 48 hours
CrCl≤20 ml/min/1.73m2 :125-250mg IV every 12 hours
CrCl 21-40 ml/min/1.73m2: 125-250mg IV every 12 hours
CrCl 41-70 ml/min/1.73m2: 250mg IV every 8 hours
CrCl≥71 ml/min/1.73m2: 250mg IV every 6 hours
Dosage Forms & StrengthsÂ
Powder for injectionÂ
250mg/250mgÂ
500mg/500mgÂ
Refer adult dosingÂ
may decrease the therapeutic effect of antibiotics
may decrease the therapeutic effect of antibiotics
may increase the adverse effect when combined with imipenem
may decrease the therapeutic effect of antibiotics
may decrease the therapeutic effect of antibiotics
may decrease the therapeutic effect of antibiotics
may increase the adverse effect when combined with imipenem
may decrease the therapeutic effect of antibiotics
may increase the neurotoxic effects of imipenem
may decrease the therapeutic effect of antibiotics
Frequency defined:Â Â
1-10%Â
EosinophiliaÂ
False positive Coombs testÂ
Transient increase in blood urea nitrogenÂ
NauseaÂ
VomitingÂ
DiarrheaÂ
PhlebitisÂ
Miscellaneous dermatologic effectsÂ
SeizuresÂ
<1%Â
AgitationÂ
AnemiaÂ
DizzinessÂ
HypersensitivityÂ
Elevated liver function testsÂ
NeutropeniaÂ
PruritisÂ
Abnormal urinalysisÂ
AnaphylaxisÂ
ConfusionÂ
DyskinesiaÂ
FeverÂ
HypotensionÂ
Increased prothrombin timeÂ
PalpitationsÂ
Pregnancy consideration:Â Â
US FDA Pregnancy calculator: Not assignedÂ
Lactation: Excretion of the drug in human breast milk is unknownÂ
Pregnancy category:Â
Category A: well-controlled and Satisfactory studies show no risk to the fetus in the first or later trimester.  Â
Category B: there was no evidence of risk to the fetus in animal studies, and there were not enough studies on pregnant women.Â
Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.   Â
Category D: adequate data available with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.   Â
Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women.   Â
Category N: There is no data available for the drug under this categoryÂ
Patient information leafletÂ
Generic Name: imipenem/cilastatinÂ
Pronounced: [ IM-i-PEN-em-and-SYE-la-STAT-in]Â
Why do we use imipenem/cilastatin?Â
It is used to treat urinary, lower respiratory tract, abdominal and gynecological infectionsÂ
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