Brand Name :
Recabrio
Synonyms :
Imipenem/ cilastatin /relebactam
Class :
Carbapenems/beta-lactamase inhibitors
Dosage Forms & Strengths
Injection, powder for reconstitution
500mg/500mg/250mg per vial
1.25
g
Injection
every 6 hours
4 - 14
days
Solution
1.25
g
Injection
every 6 hours
4 - 14
days
Solution
1.25
g
Injection
every 6 hours
4 - 14
days
Solution
Dose Adjustments
CrCl <15 ml/min: Do not use until haemodialysis is initiated
CrCl 15-29 ml/min:0.5g IV every 6 hours
CrCl 30-59 ml/min:0.75g IV every 6 hours
CrCl 60-89 ml/min:1g IV every 6 hours
Dosage Forms & Strengths
<18 years: Safety and efficacy not established
<18 years: Safety and efficacy not established
may decrease the therapeutic effect of antibiotics
may decrease the therapeutic effect of antibiotics
may decrease the therapeutic effect of antibiotics
may increase the neurotoxic effects of imipenem
may decrease the therapeutic effect of antibiotics
may decrease the therapeutic effect of antibiotics
may decrease the therapeutic effect of antibiotics
may decrease the therapeutic effect of antibiotics
Frequency defined:
1-10%
Nausea
Vomiting
Phlebitis
Hypertension
Increased lipase
Diarrhea
Headache
Increased ALT
Pyrexia
Anemia
CNS adverse effects
<1%
Increased blood creatinine
Pregnancy consideration:
US FDA: Not assigned
Lactation: Excretion of the drug in human breast milk is unknown
Pregnancy category:
Category A: well-controlled and Satisfactory studies show no risk to the fetus in the first or later trimester.
Category B: there was no evidence of risk to the fetus in animal studies, and there were not enough studies on pregnant women.
Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.
Category D: adequate data available with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.
Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women.
Category N: There is no data available for the drug under this category
Patient information leaflet
Generic Name: Imipenem/ cilastatin /relebactam
Pronounced: (IM-i-PEN-em, SYE-la-STAT-in, REL-e-BAK-tam)
Why do we use Imipenem/ cilastatin /relebactam?
It is used to treat complicated bacterial infections in the stomach and urinary tract
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