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Brand Name :
primaxin
Synonyms :
imipenem/cilastatin
Class :
Dosage Forms & Strengths
Powder for injection
250mg/250mg
500mg/500mg
skin, Gynaecology, and upper respiratory tract infections
Mild to moderate:
500 - 700
mg
Injection
every 12 hours
Solution
500
mg
Intravenous (IV)
every 6 hours
Solution
Mild to moderate:
250 - 500
mg
Injection
every 6 hours
Solution
Severe: 500mg Intravenous every 6 hours or 1g every 8 hours for 4-7 days
Uncomplicted:250mg intravenous every 6 hours
Complicated:500mg intravenous every 6 hours
Dose Adjustments
Renal impairment
CrCl<5 ml/min/1.73m2: Only use IV if hemodialysis will start within 48 hours
CrCl≤20 ml/min/1.73m2 :125-250mg IV every 12 hours
CrCl 21-40 ml/min/1.73m2: 125-250mg IV every 12 hours
CrCl 41-70 ml/min/1.73m2: 250mg IV every 8 hours
CrCl≥71 ml/min/1.73m2: 250mg IV every 6 hours
Dosage Forms & Strengths
Powder for injection
250mg/250mg
500mg/500mg
Refer adult dosing
may decrease the therapeutic effect of antibiotics
may decrease the therapeutic effect of antibiotics
may increase the adverse effect when combined with imipenem
may decrease the therapeutic effect of antibiotics
may decrease the therapeutic effect of antibiotics
may decrease the therapeutic effect of antibiotics
may increase the adverse effect when combined with imipenem
may decrease the therapeutic effect of antibiotics
may increase the neurotoxic effects of imipenem
may decrease the therapeutic effect of antibiotics
Frequency defined:
1-10%
Eosinophilia
False positive Coombs test
Transient increase in blood urea nitrogen
Nausea
Vomiting
Diarrhea
Phlebitis
Miscellaneous dermatologic effects
Seizures
<1%
Agitation
Anemia
Dizziness
Hypersensitivity
Elevated liver function tests
Neutropenia
Pruritis
Abnormal urinalysis
Anaphylaxis
Confusion
Dyskinesia
Fever
Hypotension
Increased prothrombin time
Palpitations
Pregnancy consideration:
US FDA Pregnancy calculator: Not assigned
Lactation: Excretion of the drug in human breast milk is unknown
Pregnancy category:
Category A: well-controlled and Satisfactory studies show no risk to the fetus in the first or later trimester.
Category B: there was no evidence of risk to the fetus in animal studies, and there were not enough studies on pregnant women.
Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.
Category D: adequate data available with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.
Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women.
Category N: There is no data available for the drug under this category
Patient information leaflet
Generic Name: imipenem/cilastatin
Pronounced: [ IM-i-PEN-em-and-SYE-la-STAT-in]
Why do we use imipenem/cilastatin?
It is used to treat urinary, lower respiratory tract, abdominal and gynecological infections
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