indoxacarb

Action and Spectrum

Actions and Spectrum: 

Actions: 

The insects are paralyzed or even killed because of activation of the sodium channels in indoxacarb. These channels, which are essential for the support to be supplied to nerve cells, are applied for this processing channel within the nervous system. Through its action, indoxacarb intercepts the conventional impulses of signal transmission and eventually kills the insects chosen for the effective operation.

Drug Interaction

Adverse Reaction

Adverse reaction

• Salivation
• Tremors
• Spasms
• Sudden weight loss

Black Box Warning

Black Box Warning 

None

Contraindication / Caution

Contraindication/Caution: 

Use with caution on cats and dogs under eight weeks old.

Take caution for cats less than 0.6 kg weight and for dogs less than 1.5 kg.

Pregnancy / Lactation

Pregnancy & breastfeeding:

Pregnancy consideration:  

No data is available regarding the administration of the drug during pregnancy.

Breastfeeding warnings:  

No data is available regarding the excretion of this drug in breast milk.

Pregnancy category: 

• Category A: well-controlled and satisfactory studies show no risk to the fetus in the first or later trimester.
• Category B: There was no evidence of risk to the fetus in animal studies, and there were not enough studies on pregnant women.
•  Category C: There was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.
•  Category D: Adequate data with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.
• Category X: Drugs listed in this category outweigh the risks over benefits. Hence, these categories of drugs need to be avoided by pregnant women.
• Category N: No data for the drug under this category is available.

Pharmacology

Pharmacology:

Indoxacarb acts as an insecticide, and it belongs to oxadiazine class.

Pharmacodynamics:

Indoxacarb paralyzes and kills insects by blocking their sodium channels, disrupting nerve signal transmission and causing paralysisTop of Form.

Pharmacokinetics: 

Limited data available

Adminstartion

Administration: 

Administered topically to dog and cats.

Patient Information Leaflet

Patient information leaflet 

Generic Name: indoxacarb

Why do we use indoxacarb?

The indoxacarb as an insecticide is effective in managing a diverse range of insect pests found in the agricultural, residential, and commercial areas. This drug, being a sodium channel blocker from oxadiazine chemical class works against nervous system of insect and results in their death through transportation of electric signals throughout the body.