iobenguane I-123

Action and Spectrum

Actions and Spectrum 

iobenguane I-123 is a radiolabelled analog of norepinephrine and acts as a radiotracer. It works by binding to norepinephrine transporters (NETs) on the surface of certain cells, particularly of the adrenal medulla and sympathetic nervous system.

Drug Interaction

Adverse Reaction

Frequency not defined  

Dizziness 

Injection site hemorrhage 

Flushing 

Pruritus  

Rash 

Post marketing Reports 

Hypersensitivity 

Black Box Warning

Black Box Warning 

None

Contraindication / Caution

Contraindication/Caution: 

Contraindication: 

• iobenguane I-123 should not be administered to individuals with a known hypersensitivity or allergic reaction to the drug or any of its components. 

Caution: 

• Caution should be taken to minimize radiation exposure to the patient. 
• Caution should be taken to avoid unnecessary radiation exposure to the developing fetus. 
• Careful consideration and adjustment of the dose may be necessary in renal impairment patients.

Pregnancy / Lactation

Pregnancy consideration: 

Pregnancy category: N/A 

Lactation: It is present in human breast milk  

Pregnancy Categories:         

Category A: well-controlled and Satisfactory studies show no risk to the fetus in the first or later trimester. 

Category B: there was no evidence of risk to the fetus in animal studies, and there were not enough studies on pregnant women.  

Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women. 

Category D: adequate data with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits. 

Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women. 

Category N: There is no data available for the drug under this category. 

Pharmacology

Pharmacology  

iobenguane I-123 is a synthetic analog of norepinephrine, a neurotransmitter involved in the sympathetic nervous systems signaling.  

Radiotracers are compounds that emit radiation that can be detected externally using specialized imaging equipment. 

Pharmacodynamics 

iobenguane I-123 circulates in the bloodstream and is actively taken up by cells expressing NETs. In the adrenal medulla, it accumulates in specialized cells called chromaffin cells.  

Pharmacokinetics 

Absorption   

iobenguane I-123 administered intravenously, directly into the vein. 

Distribution 

iobenguane I-123 distributes throughout the body. 

Metabolism 

iobenguane I-123 is not significantly metabolized within the body.  

Elimination and excretion 

iobenguane I-123 is excreted primarily through the kidneys. The half-life of drug is around 13.2 hours. 

Adminstartion

Administration 

iobenguane I-123 is administered as intravenous injection directly into a bloodstream. 

Patient Information Leaflet

Patient information leaflet 

Generic Name: iobenguane I-123 

Why do we use iobenguane I-123? 

iobenguane I-123 is used for the imaging and evaluation of neuroendocrine tumors, particularly pheochromocytoma and paraganglioma. iobenguane I-123 is used for the evaluation of cardiac sympathetic innervation in patients with heart failure or certain arrhythmias.