iobitridol

Action and Spectrum

Actions and Spectrum 

Radiocontrast agents are substances used in medical imaging procedures, such as X-rays, computed tomography (CT) scans, and other radiographic studies, to enhance the visibility of specific structures or organs within the body.

These agents contain elements, like iodine in the case of iobitridol, that readily absorb X-rays, improving contrast in the resulting images. iobitridol’s ability to absorb X-rays allows for better visualization of internal structures, aiding in diagnosing and assessing various medical conditions.

Drug Interaction

Adverse Reaction

Frequency not defined 

Shock 

Circulatory arrest 

Black Box Warning

Black Box Warning: 

None 

Contraindication / Caution

Contraindication/Caution: 

Contraindications: 

• Hypersensitivity 
• Renal impairment 
• Thyroid disorders 

Cautions: 

• Mild to moderate allergies 
• Asthma 
• Dehydration 
• Diabetes 
• Elderly patients 
• Pregnancy 
• Breastfeeding 

Pregnancy / Lactation

Pregnancy consideration:  

The drug crosses the placenta, hence should be avoided during pregnancy. 

Breastfeeding warnings:  

iobitridol is excreted in small amounts in breast milk; hence, utilize it cautiously. 

Pregnancy category: 

Category A: well-controlled and satisfactory studies show no risk to the fetus in the first or later trimester. 

Category B: there was no evidence of risk to the fetus in animal studies, and there were not enough studies on pregnant women. 

Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.    

Category D: adequate data with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.    

Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women.    

Category N: No data is available for the drug under this category. 

Pharmacology

Pharmacology:  

Iobitridol contains iodine atoms, which have a high atomic number and thus absorb X-rays effectively. When introduced into the body, iobitridol accumulates in blood vessels and organs, increasing the contrast in radiographic images. This allows healthcare professionals to visualize and assess the structures and functions of various organs and blood vessels. 

Pharmacodynamics: 

The primary pharmacodynamic effect of iobitridol is the enhancement of contrast in medical images. Contrast refers to the difference in X-ray absorption between different tissues or structures within the body. Because iobitridol absorbs X-rays more readily than the surrounding tissues, it increases the contrast between blood vessels and other structures, making them more visible in the resulting images. 

Pharmacokinetics: 

Absorption 

Iobitridol is typically administered intravenously. After injection. 

Distribution 

it distributes throughout the bloodstream, with a concentration peak shortly after administration. 

Metabolism 

iobitridol is minimally metabolized in the body. 

Elimination and Excretion 

It is eliminated from the body mainly through renal excretion, with a relatively short half-life. 

Adminstartion

Administration: 

• Intravenous Access: A sterile intravenous (IV) line will be inserted into the arm or hand vein. This allows direct access for administering the contrast agent and other necessary medications. 
• Patient Positioning: The patient will be positioned appropriately for imaging, such as lying on a CT scanner or an angiography table. 
• Contrast Injection: The iobitridol contrast agent will be prepared in a sterile container and injected into the IV line. The rate of injection and the total amount of contrast used depend on the specific imaging procedure and the patient’s characteristics. 
• Monitoring: Healthcare providers will closely monitor the patient’s vital signs and any potential reactions to the contrast agent throughout the procedure. This is especially important during the first minutes after the injection, as allergic reactions can occur. 
• Imaging: Once the contrast agent has been administered, the medical imaging procedure (e.g., CT scan, angiogram) will begin. The contrast-enhanced images will help visualize blood vessels, tissues, and organs more clearly than without the contrast agent. 

Patient Information Leaflet

Patient information leaflet 

Generic Name: iobtiridol 

Pronounced as: i-o-bit-ri-dol 

Why do we use iobitridol? 

iobitridol contains iodine atoms with a high atomic number and readily absorbs X-rays. When introduced into the body, iobitridol accumulates in the area of interest, such as blood vessels or specific organs. This increased iodine concentration leads to better absorption of X-rays, resulting in improved contrast between the targeted structures and surrounding tissues. As a result, medical professionals can more clearly visualize and assess the anatomical and functional details of the body.