- March 15, 2022
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Brand Name :
Yervoy
Synonyms :
ipilimumab
Class :
Antineoplastics and Monoclonal Antibody
Dosage Forms & Strengths
Injectable solution- single dose
5mg per ml
3 mg per kg given IV over 90 minutes every three weeks for a maximum of 4 doses
Adjuvant treatment of melanoma:
10 mg per kg given IV over 90mins every three weeks for four doses, followed by 10 mg per kg given IV over 90mins every 12 weeks for up to 3yrs
ipilimumab 1 mg per kg given IV over 30 minutes every 3 weeks with nivolumab 3 mg per kg given IV over 30 minutes on the same day for 4 doses
After completing four doses of combination, nivolumab is given as a single agent
Continue the treatment until disease progression or unacceptable toxicity occurs
ipilimumab 1 mg per kg given IV over 30 minutes every 3 weeks with nivolumab 3 mg per kg given IV over 30 minutes on the same day for 4 doses
After completing four doses of combination, nivolumab is given as a single agent
Continue the therapy until disease progression or unacceptable toxicity occurs
ipilimumab 3 mg per kg given IV over 30 minutes every 3 weeks with nivolumab 1mg per kg given IV over 30 minutes on the same day for 4 doses
After completing four doses of combination, nivolumab is given as a single agent.
Continue the therapy until disease progression or unacceptable toxicity occurs.
Dosage Forms & Strengths
Injectable solution- single dose
5mg per ml
Age: >12yrs
3 mg per kg given IV over 90 minutes every three weeks for a maximum of 4 doses
Adjuvant treatment of melanoma:
10 mg per kg given IV over 90mins every three weeks for four doses, followed by 10 mg per kg given IV over 90mins every 12 weeks for up to 3yrs
Age:>12yrs
ipilimumab 1 mg per kg given IV over 30 minutes every 3 weeks with nivolumab 3 mg per kg given IV over 30 minutes on the same day for 4 doses
After completing four doses of combination, nivolumab is given as a single agent.
Continue the therapy until disease progression or unacceptable toxicity occurs.
when both drugs are combined, there may be an increased risk of adverse effects
when both drugs are combined, there may be an increased risk of adverse effects
when both drugs are combined, there may be an increased risk of adverse effects
when both drugs are combined, there may be an increased risk of adverse effects
when both drugs are combined, there may be an increased risk of adverse effects
when both drugs are combined, there may be an increased risk of adverse effects
when both drugs are combined, there may be an increased risk of adverse effects
when both drugs are combined, there may be an increased risk of adverse effects
It may enhance the immunosuppressive effects when combined with idecabtagene vicleucel
when both drugs are combined, there may be an increased risk of infection
when both drugs are combined, there may be an increased risk of infection
when both drugs are combined, there may be an increased risk of infection
when both drugs are combined, there may be an increased risk of infection
when both drugs are combined, there may be an increased risk of infection
when both drugs are combined, there may be an increased risk of infection
it may enhance the adverse effects when combined with aducanumab
It may enhance the adverse effects when combined with sotrovimab
Adverse drug reactions:
>10%
Diarrhea
Dermatitis immune-mediated manifestations
Fatigue
Pruritus
Rash
1-10%
Colitis
Conjunctivitis
Immune-mediated enterocolitis
Immune-mediated hepatitis
Myocarditis
Meningitis
Pericarditis
Angiopathy
Temporal arteritis
Vasculitis
Polymyalgia rheumatica
Pregnancy warnings:
Breastfeeding warnings:
Pregnancy Categories:
Patient Information Leaflet
Generic Name: ipilimumab (Rx)
Pronounced: moe- gam -ue- liz -ue-mab
Why do we use ipilimumab?
ipilimumab is an anticancer drug used to treat melanoma (skin cancer). It inhibits the growth and spread of cancer cells.
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