isoniazid

DRUG INTERACTION

Contraindicated  

Serious Use Alternative  

Monitor Closely  

Minor  

Frequency defined:  

>10% 

Peripheral neuropathy 

Nausea 

Stomach pain 

Loss of appetite 

Vomiting 

Weakness 

1-10% 

Slurred speech 

Progressive liver damage 

Dizziness 

Lethargy 

Hyperreflexia 

<1% 

Anemia 

Thrombocytopenia 

Agranulocytosis 

Megaloblastic anemia 

Systemic lupus erythematous 

Pregnancy consideration: C 

Lactation: The drug is excreted in the human breast milk and is safe for nursing women  

Pregnancy category: 

Category A: well-controlled and Satisfactory studies show no risk to the fetus in the first or later trimester.   

Category B: there was no evidence of risk to the fetus in animal studies, and there were not enough studies on pregnant women. 

Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.    

Category D: adequate data available with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.    

Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women.    

Category N: There is no data available for the drug under this category 

Patient information leaflet 

Generic Name: isoniazid 

Pronounced: [ eye-so-NYE-a-zid ] 

Why do we use isoniazid? 

Isoniazid is an antibiotic used to treat and prevent tuberculosis (TB). It belongs to a class of antibiotics called antituberculosis agents. Isoniazid is used to treat TB infections in the lungs and other parts of the body. It is typically used in combination with other TB medications to ensure that the infection is fully treated and to prevent the development of drug-resistant TB