Evaluating Match Rates Between OASIS Assessments and Medicare Claims Data
April 4, 2026
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Brand Name :
Motiza MPS, Itokine MPS
Synonyms :
itopride/methyl polysiloxane
Class :
Motility stimulant and Anti-flatulent
Brand Name :
Motiza MPS, Itokine MPS
Synonyms :
itopride/methyl polysiloxane
Class :
Motility stimulant and Anti-flatulent
Dosage Forms & Strengths
Tablet
50mg/125mg
(itopride/methyl polysiloxane)
Take one tablet orally three times in a day
Not determined
Refer to adult dosing
Actions and Spectrum
itopride works as a prokinetic agent. It enhances gastrointestinal motility by blocking the enzyme acetylcholinesterase and increasing the release of acetylcholine, a neurotransmitter that promotes muscle contractions in the digestive tract.
methyl polysiloxane is primarily used as an antifoaming agent in medications for gastrointestinal issues. It works by breaking down and preventing the formation of gas bubbles in the intestines and stomach.
Black Box Warning
None
Contraindication/Caution:
Contraindication:
Caution:
Pregnancy consideration:
Pregnancy category: N/A
Lactation: Excretion into human milk is unknown
Pregnancy Categories:
Category A: well-controlled and Satisfactory studies show no risk to the fetus in the first or later trimester.
Category B: there was no evidence of risk to the fetus in animal studies, and there were not enough studies on pregnant women.
Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.
Category D: adequate data with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.
Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women.
Category N: There is no data available for the drug under this category.
Pharmacology
itopride works primarily by blocking the enzyme acetylcholinesterase, which breaks down acetylcholine. acetylcholine is available to stimulate muscle contractions, thereby increasing motility in the stomach and intestines.
methyl polysiloxane reduces surface tension at the gas-liquid interface, allowing gas bubbles to coalesce and be expelled more easily. This action helps to relieve symptoms of excess gas and bloating.
Pharmacodynamics
The enhanced motility of itopride can alleviate symptoms associated with slow or impaired gastric emptying. This leads to enhanced gastric motility and improved emptying of the stomach contents.
methyl polysiloxane helps break down and prevent the formation of gas bubbles in the intestines and stomach. This action allows gas bubbles to coalesce and be expelled more easily, reducing the overall volume of gas in the GI tract.
Pharmacokinetics
Absorption
itopride/methyl polysiloxane is absorbed from the gastrointestinal tract into the bloodstream.
Distribution
itopride/methyl polysiloxane is distributed throughout the body.
Metabolism
itopride/methyl polysiloxane undergoes extensive metabolism in the liver.
Elimination and excretion
itopride/methyl polysiloxane is excreted through the urine and feces.
Administration
itopride/methyl polysiloxane is a combination drug available in form of table for oral tablet.
Patient information leaflet
Generic Name: itopride/methyl polysiloxane
Why do we use itopride/methyl polysiloxane?
Motiza MPS (itopride/methyl polysiloxane) is a combination drug used to treat dyspepsia with flatulence.
It is also used to manage functional gastrointestinal disorders and indigestion issues.
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