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Brand Name :
Klinique Active, ketamide, Ketostar
Synonyms :
ketoconazole/cetrimide
Class :
Antifungal and Antiseptic agent
Brand Name :
Klinique Active, ketamide, Ketostar
Synonyms :
ketoconazole/cetrimide
Class :
Antifungal and Antiseptic agent
Dosage Forms & Strengths
Lotion
100 ml
Soap
75 gm
Apply sufficient quantity of lotion on the scalp topically one time daily for a week
Dosage Forms & Strengths
Lotion
100 ml
Soap
75 gm
For 13 to 18 years old:
Apply sufficient quantity of lotion on the scalp topically one time daily for a week
Refer to adult dosing
Actions and Spectrum
ketoconazole having antifungal properties. It works by inhibiting the synthesis of ergosterol, a key component of the fungal cell membrane. This disruption in the fungal cell membrane structure weakens the cell, leading to its death.
cetrimide is not a medication for treating fungal infections. Instead, it is an antiseptic and disinfectant agent. It is effective in killing or inhibiting the growth of a wide range of bacteria and fungi.
Frequency not defined
Burning
Irritation
Itching
Black Box Warning
None
Contraindication/Caution:
Contraindication:
Caution:
Pregnancy consideration:
Pregnancy category: N/A
Lactation: Excretion into human milk is unknown
Pregnancy Categories:
Category A: well-controlled and Satisfactory studies show no risk to the fetus in the first or later trimester.
<b>Category B: there was no evidence of risk to the fetus in animal studies, and there were not enough studies on pregnant women.
Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.
Category D: adequate data with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.
Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women.
Category N: There is no data available for the drug under this category.
Pharmacology
ketoconazole blocks the activity of an enzyme lanosterol 14-alpha-demethylase, which is essential for the conversion of lanosterol to ergosterol in fungi. Without ergosterol, the fungal cell membrane becomes structurally unstable, leading to cell death.
cetrimide is an ammonium compound that primarily acts as an antiseptic and disinfectant. It disrupts the cell membranes of bacteria and some other microorganisms, leading to cell death. It has both bactericidal and bacteriostatic properties.
Pharmacodynamics
ketoconazole accomplishes this by blocking the activity of lanosterol 14-alpha-demethylase. This disruption in fungal cell membrane structure weakens the cell, leading to its death.
cetrimide is cationic and interacts with negatively charged components on the microbial cell surface, leading to membrane damage and cell death.
Pharmacokinetics
Limited information available on ADME.
Administration
ketoconazole/cetrimide is a combination drug available in topical forms such as lotions, soaps, and creams.
Patient information leaflet
Generic Name: ketoconazole/cetrimide
Why do we use ketoconazole/cetrimide?
Klinique Active (ketoconazole/cetrimide) is a combination drug used as antifungal and antiseptic agent to treat various skin and hair infections. ketoconazole/cetrimide is used to control dandruff and seborrheic dermatitis of the scalp.
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