Detection of Suspected Paper Mill Publications in Cancer Research Using Machine Learning
January 30, 2026
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Brand Name :
Staladex
Synonyms :
leuprorelin implant
Class :
Gonadotrophin agent, Gonadotrophin-Releasing Hormone Antagonists and Gonadorelin Analogues
Brand Name :
Staladex
Synonyms :
leuprorelin implant
Class :
Gonadotrophin agent, Gonadotrophin-Releasing Hormone Antagonists and Gonadorelin Analogues
Dosage Forms & Strengths
Implant
10.72 mg
Castration-Resistant Prostate Cancer (CRPC)
Administer one implant once every 3 months
Not determined
Action and spectrum:
Leuprorelin is a synthetic analog of gonadotrophin-releasing hormone (GnRH). It increased potency and resistance to proteolysis. It will work as a GnRH agonist which tightly binds to the GnRH receptor on anterior pituitary cells.
Frequency not defined
Fatigue
Pulmonary embolism
Blood glucose disturbances
Bone pain
Injection site reactions
Nausea
Dysgeusia
Hot flushes
Visual disturbances
Increased appetite
Headache
Night sweats
Joint pain
Mood changes
Nocturia
Vomiting
Fever
Black box warning
None
Contraindication/Caution:
Contraindications
Cautions
Pregnancy Warnings:
Pregnancy category: N/A
Lactation: Excretion of the drug into the human breast milk is unknown
Pregnancy categories:
Category A: Satisfactory and well-controlled studies show no evidence of risk to the fetus in the first trimester or in the later trimester.
Category B: No evidence of risk to fetus found in animal reproduction studies and there are not enough studies on pregnant women.
Category C: Adverse effects on the fetus found with evidence in animal reproduction studies and no adequate evidence for an effect in humans, care must be taken for potential risks in pregnant women.
Category D: There is adequate data available with sufficient evidence of human fetal risk from various platforms, but despite potential risks may be used only in emergency cases for potential benefits.
Category X: Drugs listed in this category clearly outweigh risks over benefits. These category drugs should be prohibited for pregnant women.
Category N: There is no data available for the drug under this category.
Pharmacology:
leuprolide acts as a pituitary GnRH receptor agonist which initiates the secretion of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) in the anterior pituitary.
This shift leads to decrease in LH and FSH levels. In males, this reduction results in decreased testosterone levels to castrate levels.
Pharmacodynamics:
Limited information is available.
Pharmacokinetics:
Limited information is available on ADME.
Administration:
It is administered via abdominal subcutaneous injection i.e., injecting into the fatty tissue just beneath the skin in the abdominal area.
Patient information leaflet
Generic Name: leuprorelin implant
Why do we use leuprorelin implant?
Leuprorelin implant is used in the treatment of advanced prostate cancer.
It also effective in breast cancer treatment specially in premenopausal women.
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