lomefloxacin

Action and Spectrum

Actions and Spectrum: 

Action: lomefloxacin exerts its antibacterial action by interfering with DNA gyrase and topoisomerase IV enzymes, essential for DNA replication, recombination, and repair in bacteria. By inhibiting these enzymes, lomefloxacin prevents the supercoiling of bacterial DNA, disrupting DNA synthesis and ultimately bacterial cell death. 

Spectrum: lomefloxacin has a broad spectrum of activity against various Gram-positive and Gram-negative bacteria. It is effective against many pathogens commonly associated with respiratory, urinary, and genital tract infections. 

Drug Interaction

Adverse Reaction

Frequency not defined  

Nausea 

Headache 

Drowsiness 

constipation 

Black Box Warning

Black Box Warning:  

None

Contraindication / Caution

Contraindication/Caution:  

Hypersensitivity: lomefloxacin should not be used in individuals with known hypersensitivity or allergy to lomefloxacin or other quinolone antibiotics. 

Tendon Disorders: lomefloxacin may increase the risk of tendon disorders, including tendonitis and tendon rupture. It should be avoided in individuals with a history of such issues. 

Children and Adolescents: lomefloxacin is generally not recommended for use in children and adolescents, as it may adversely affect developing cartilage and joints. 

Pregnancy and Breastfeeding: lomefloxacin should be administered during pregnancy or breastfeeding in situations where the advantages surpass any potential risks to the developing fetus or nursing child. 

Pregnancy / Lactation

Pregnancy warnings:     

Pregnancy category: N/A 

Lactation: Excreted into human milk is unknown 

Pregnancy Categories:         

Category A: Studies that were well-controlled and met expectations revealed no risk to the fetus in either the first or second trimester. 

Category B: There were a lack of studies on pregnant women and no evidence of risk to the fetus in animal experiments.   

Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.    

Category D: adequate data with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.   

Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women.    

Category N: There is no data available for the drug under this category

Pharmacology

Pharmacology: lomefloxacin is an antibiotic belonging to the fluoroquinolone class of drugs. 

Pharmacodynamics:  

lomefloxacin works by inhibiting the bacterial DNA gyrase and topoisomerase IV enzymes. These enzymes are essential for DNA replication, recombination, repair, and bacterial transcription. By inhibiting them, lomefloxacin interferes with bacterial DNA synthesis, leading to the death of susceptible bacteria. 

Pharmacokinetics: 

Absorption 

lomefloxacin is well absorbed when taken orally. Its bioavailability is around 98%. 

Distribution 

It has good tissue penetration and can reach therapeutic concentrations in various body tissues and fluids, including the respiratory tract, urinary tract, skin, and soft tissues. 

Metabolism 

lomefloxacin undergoes minimal metabolic processes within the body, with its primary elimination route being through unchanged excretion in the urine. 

Excretion and Elimination 

The half-life of lomefloxacin is around 7 to 8 hours in adults. It is primarily eliminated through renal excretion, with approximately 85% of the drug excreted unchanged in the urine. 

Adminstartion

Administration:  

lomefloxacin is typically available in tablet form. Swallow the tablet(s) whole with a full glass of water. 

Patient Information Leaflet

Patient information leaflet 

Generic Name: lomefloxacin 

Why do we use lomefloxacin?  

lomefloxacin is often prescribed to treat uncomplicated and complicated UTIs caused by susceptible bacteria. It can be effective against both lower and upper urinary tract infections. 

lomefloxacin may be used to treat respiratory tract infections, such as bronchitis and pneumonia, when the causative organisms are susceptible to this antibiotic. 

Sometimes, lomefloxacin can treat skin and soft tissue infections caused by susceptible bacteria. 

lomefloxacin may be prescribed for treating bacterial prostatitis, an infection of the prostate gland. 

Sometimes, lomefloxacin may treat bone and joint infections, particularly if susceptible bacteria cause them.